Fig. 7

Pantothenate corrected PANK2 and mtACP deficiency in mutant PANK2 induced neurons. a Immunoblotting analysis of cellular extracts from Control (C) and patient P1 induced neurons treated with 500 μM pantothenate during 20 days. Protein extracts (5 μg) were separated on a SDS polyacrylamide gel and immunostained with antibodies against PANK2 and mtACP. Tau expression levels in induced neurons were used as loading control. b Densitometry of the Western blotting. Data represent the mean ± SD of three separate experiments. *p < 0.01 between Control and mutant PKAN induced neurons. ^ap < 0.01 between untreated and treated induced neurons. A.U., arbitrary units