| |
Rate per 100,000 PMs among SMA cases (N = 5354) (IR [95% CI])
|
Rate per 100,000 PMs among non-SMA matched controls (N = 5354) (IR [95% CI])
|
Incidence rate ratioa (95% CI)
|
|---|
|
Incident hydrocephalus events
|
42
|
9
| |
|
Overall incidence rate
|
15.5 (11.2–20.9)
|
3.3 (1.5–6.3)
|
4.7 (2.4–10.2)
|
|
Incidence rate by sex
|
|
Female
|
13.9 (8.2–21.9)
|
2.3 (0.5–6.7)
|
6.0 (1.9–25.7)
|
|
Male
|
17.0 (10.9–25.3)
|
4.2 (1.6–9.2)
|
4.0 (1.7–10.8)
|
|
Incidence rate by age at index date (years)
|
|
< 1
|
50.7 (6.1–183.3)
|
0.00
|
N/C
|
|
1 to < 2
|
55.5 (11.4–162.1)
|
0.00
|
N/C
|
|
2 to < 13
|
17.3 (5.6–40.4)
|
3.4 (0.1–19.1)
|
5.1 (0.7–120.1)
|
|
13 to ≤ 20
|
16.6 (3.4–48.5)
|
5.5 (0.1–30.7)
|
3.0 (0.3–79.3)
|
|
21 to ≤ 30
|
9.8 (1.2–35.5)
|
0.00
|
N/C
|
|
31 to ≤ 40
|
0.00
|
0.00
|
N/C
|
|
41 to ≤ 50
|
2.8 (0.1–15.9)
|
2.8 (0.1–15.9)
|
1.0 (0.0–39.0)
|
|
> 50
|
21.7 (14.2–31.8)
|
5.0 (1.8–10.9)
|
4.4 (1.9–11.6)
|
- CI confidence interval, IR incidence rate, IRR incidence rate ratio, N/C not calculable, PM person-month, SMA spinal muscular atrophy
- a95% CI for IRR not calculated due to small sample size
