|
Category
|
SMA cases (N = 5354)
|
SMA cases who developed hydrocephalus (N = 42)
|
Non-SMA matched controls (N = 5354)
|
Non-SMA matched controls who developed hydrocephalus (N = 9)
|
|---|
|
Age at index date (years)
|
|
Mean
|
45.0
|
46.9
|
45.0
|
59.7
|
|
Median
|
45
|
57
|
45
|
70
|
|
Min, max
|
0, 86
|
0, 86
|
0, 86
|
8, 85
|
|
SD
|
23.65
|
30.59
|
23.65
|
27.99
|
|
Age (years) at index date categories (n, %)
|
|
0 to < 1
|
95 (1.8)
|
2 (4.8)
|
95 (1.8)
|
0 (0.0)
|
|
1 to < 2
|
114 (2.1)
|
3 (7.1)
|
114 (2.1)
|
0 (0.0)
|
|
2 to < 13
|
442 (8.3)
|
5 (12)
|
442 (8.3)
|
1 (11.0)
|
|
13 to ≤ 20
|
326 (6.1)
|
3 (7.1)
|
326 (6.1)
|
1 (11.0)
|
|
21 to ≤ 30
|
436 (8.1)
|
2 (4.8)
|
436 (8.1)
|
0 (0.0)
|
|
31 to ≤ 40
|
926 (17.0)
|
0 (0.0)
|
926 (17.0)
|
0 (0.0)
|
|
41 to ≤ 50
|
653 (12.0)
|
1 (2.4)
|
653 (12.0)
|
1 (11.0)
|
|
> 50
|
2362 (44.0)
|
26 (62.0)
|
2362 (44.0)
|
6 (67.0)
|
|
Sex (n, %)
|
|
Female
|
2521 (47.0)
|
18 (43.0)
|
2521 (47.0)
|
3 (33.0)
|
|
Male
|
2833 (53.0)
|
24 (57.0)
|
2833 (53.0)
|
6 (67.0)
|
|
Time in database (months)
|
|
Mean
|
90.6
|
96.5
|
90.6
|
136.4
|
|
Median
|
93
|
107.5
|
93
|
159
|
|
SD
|
46.65
|
54.66
|
46.65
|
42.69
|
- SD standard deviation, SMA spinal muscular atrophy
