Table 1 Patients and relatives socio-demographic characteristics and patients’ clinical variables
Patients (N = 141) | Relatives (N = 69) | |||
|---|---|---|---|---|
N | % | N | % | |
Socio-demographic characteristics | ||||
Gender | ||||
Males | 106 | 75.2 | 15 | 21.7 |
Females | 35 | 24.8 | 54 | 78.3 |
Age, mean ± SD | 66.1 ± 11.09 | 57.2 ± 11.8 | ||
Marital status | ||||
Free | 34 | 25.2 | 9 | 10.5 |
Married | 101 | 74.8 | 60 | 89.6 |
Education | ||||
Primary school | 18 | 14.3 | 10 | 14.7 |
Secondary school | 42 | 33.3 | 14 | 20.6 |
High school | 44 | 34.9 | 32 | 47.1 |
University | 22 | 17.5 | 12 | 17.7 |
Employed, yes | 41 | 29.5 | 32 | 47.1 |
Relationship with the patient | – | |||
Spouse | 51 | 75.0 | ||
Other | 17 | 25.0 | ||
Daily hours spent in caregiving, mean ± SD | – | 8.1 ± 9.7 | ||
Clinical variables | ||||
Mutation | ||||
Val30Met | 39 | 27.6 | ||
Phe64Leu | 33 | 23.4 | ||
Glu89Gln | 25 | 17.7 | ||
Ile68Leu | 14 | 9.9 | ||
Val122Ile | 7 | 5 | ||
Tyr78Phe | 7 | 5 | ||
Thr49Ala | 6 | 4.3 | ||
Other (n. 9) | 10 | 7.1 | ||
Phenotype | – | |||
ATTRv-PN | 111 | 78.7 | ||
ATTRv-CM | 30 | 21.3 | ||
ATTRv stage | – | |||
0 | 6 | 4.3 | ||
1 | 75 | 53.2 | ||
2 | 42 | 29.8 | ||
3 | 18 | 12.8 | ||
Age at symptom onset, mean ± SD | 59.8 ± 11.8 | – | ||
Length of symptom in years, mean ± SD | 6.2 ± 4.2 | – | ||