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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: Hypertrophy of unaffected cardiomyocytes correlates with severity of cardiomyopathy in female patients with Fabry disease

Fig. 1

a Mosaic with normal and affected myocytes. (H&E 200×) in a female with pre-hypertrophic Fabry Cardiomyopathy (10.3 mm LVMWT and preserved EF (58%). Insert shows accumulation of glycolipids in the form of myelin bodies. b Moderate hypertrophy of unaffected myocytes in Fabry female with moderate LV hypertrophy (17 mm LV MWT and EF 55%). c Severe hypertrophy with disarray of unaffected myocytes interspersed with enlarged vacuolated cells. (H&E ×200) in a Fabry female with severe LV hypertrophy (LV MWT 22 mm, Left Bundle Branch Block, AV block, implanted Pace-Maker, EF 30%, died because of heart failure). Insert shows accumulation of glycolipids in the form of myelin bodies. d correlation between MWT and diameter of non affected cells showing a linear correlation

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172