Table 1 Base-case values of the model parameters

Iron chelation therapy

DFO (per gram)

[28]

DFX (per gram)

DFP (per gram)

Prescribed dosage (mg/kg/day)

DFO

[23]

DFX

DFP

[2]

Administration (monthly cost)

DFO^c

[28]

DFX

DFP

Routine laboratory and instrumental monitoring test (monthly cost)

TDT patient < 10 years old

[29, 35]

TDT patient ≥ 10 years old

Blood transfusion cost (per transfusion)

per millilitre^d

[3, 35]

Blood group and cross matching test

Blood transfusion equipment

Compliance (%)

DFO-DFP

[10]

 DFO arm

 DFP arm

DFX

Cost of IOL complications

Cardiac complication, year 1

[31]

Cardiac complication, year 2+

Diabetes mellitus, year 1

[34]

Diabetes mellitus, year 2+

Hypogonadism, year 1

[28, 35]

Hypogonadism, year 2+

Hypoparathyroidism, year 1

Hypoparathyroidism, year 2+

Hypothyroidism, year 1

Hypothyroidism, year 2+

Annual mortality with cardiac disease (%)

[26]

Relative risk of death, TDT vs general population

[23]