|
Iron chelation therapy
|
|
DFO (per gram)
|
10.81
|
44.00
| |
[28]
|
|
DFX (per gram)
|
36.60
|
149.00
| |
|
DFP (per gram)
|
0.49
|
2.00
| |
|
Prescribed dosage (mg/kg/day)
|
|
DFO
| | |
47.4
|
[23]
|
|
DFX
| | |
24.6
|
|
DFP
| | |
75.0
|
[2]
|
|
Administration (monthly cost)
|
|
DFOc
|
96.80
|
393.98
| |
[28]
|
|
DFX
|
0
|
0
| |
|
DFP
|
0
|
0
| |
|
Routine laboratory and instrumental monitoring test (monthly cost)
|
|
TDT patient < 10 years old
|
55.39
|
225.42
| |
[29, 35]
|
|
TDT patient ≥ 10 years old
|
106.47
|
433.33
| |
|
Blood transfusion cost (per transfusion)
|
|
per millilitred
|
0.16
|
0.67
| |
[3, 35]
|
|
Blood group and cross matching test
|
2.7
|
11
| |
|
Blood transfusion equipment
|
1.14
|
4.64
| |
|
Compliance (%)
|
|
DFO-DFP
| | | |
[10]
|
|
DFO arm
| | |
77.3
|
|
DFP arm
| | |
90.3
|
|
DFX
| | |
98.1
|
|
Cost of IOL complications
|
|
Cardiac complication, year 1
|
536.36
|
2183.00
| |
[31]
|
|
Cardiac complication, year 2+
|
|
Diabetes mellitus, year 1
|
323.10
|
1315.00
| |
[34]
|
|
Diabetes mellitus, year 2+
|
|
Hypogonadism, year 1
|
175.40
|
713.88
| |
[28, 35]
|
|
Hypogonadism, year 2+
|
709.69
|
2888.42
| |
|
Hypoparathyroidism, year 1
|
128.72
|
523.88
| |
|
Hypoparathyroidism, year 2+
|
580.41
|
2362.27
| |
|
Hypothyroidism, year 1
|
40.43
|
164.57
| |
|
Hypothyroidism, year 2+
|
43.59
|
177.40
| |
|
Annual mortality with cardiac disease (%)
| | |
0.0062
|
[26]
|
|
Relative risk of death, TDT vs general population
| | |
3.9
|
[23]
|
