Table 3 Subgroup comparison analysis between NF1 patients with and without HSs

Age (Mean ± SD)

33 ± 17.1

31.9 ± 17.4

36.8 ± 15.5

ns^b

Gender (n)

 Males

110

79

31

ns^a

 Females

139

110

29

NIH diagnostic Criteria (%)

 Café-au-lait spots

98.1

97.8

100

ns^a

 Freckling

91.3

92.1

85.7

ns^a

 Lisch nodules

88

86.2

93.3

ns^a

 Neurofibromas

77.5

74.8

95.2

0.047^a

 Optic pathway gliomas

9.6

9.5

10

ns^a

 Distinctive osseous lesions

2.5

2.2

4.8

ns^a

 First-degree relative affected

44.5

46.3

33.3

ns^a

 Choroidal nodules^c

95.6

94.7

98.3

ns^a

 Retinal Microvascular Abnormalities^c

32.1

28

45

0.017^a

NF1 severity grading (%)

 1

15.8

18.1

3.3

ns^a

 2

58.4

57.5

63.3

ns^a

 3

13.2

12.5

16.7

ns^a

 4

12.6

11.9

16.7

ns^a