Table 2 Frequency of the NIH diagnostic criteria, NF-1-related choroidal nodules, retinal microvascular abnormalities and HSs between patients and controls

Café-au-lait spots

98.1

0

< 0.001^a

Freckling

91.3

0

< 0.001^a

Lisch nodules

88

0

< 0.001^a

Neurofibromas

77.5

0

< 0.001^a

Optic pathway gliomas

9.6

0

< 0.001^a

Distinctive osseous lesions

2.5

0

< 0.001^a

First-degree relative affected

44.5

2.7

< 0.001^a

Choroidal nodules^b

95.6

0

< 0.001^a

Retinal Microvascular Abnormalities^b

32.1

0

< 0.001^a

Hyperpigmented Spots^b

24.1

0

< 0.001^a