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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: New insights in phenotype and treatment of lung disease immuno-deficiency and chromosome breakage syndrome (LICS)

Fig. 2

Images of patient A diagnosed with LICS: a facial appearance. b Chest X-ray on day of admission showing bilateral interstitial infiltrates. c corresponding chest CT scan showing bilateral ground glass haziness, interlobar thickening and pneumomediastinum. e Lung tissue: overview showing pathological pattern of classic diffuse alveolar damage with extensive thickening of alveolar septa with early interstitial fibrosis (hematoxylin and eosin, scale bar 1 mm). g Lung tissue: Magnification: more detailed view, in which remnants of alveoli can be discerned with hyaline membranes, extensive metaplastic squamous alveolar epithelium and widened alveolar septa with variable inflammation and variable stages of fibrosis (hematoxylin and eosin, scale bar 200 micron)

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