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Table 2 Plasma total homocysteine concentrations (tHcy) before and during treatment (i.e. at the time of the survey)

From: Homocystinuria patient and caregiver survey: experiences of diagnosis and patient satisfaction

  tHcy (µmol/l) before treatment median (range) [n] tHcy (µmol/l) at survey median (range) [n] Statistical significance of difference [pairwise comparisons n] t-values
All CBS-deficient patients 257 (50–640) [44] 50 (6–310) [61] P < 0.001 [37]
10.804
Pyridoxine nonresponsive 200 (50–640) [20] 52 (6–310) [34] P < 0.001 [15]
6.837
Partially pyridoxine responsive 300 (99–412) [7] 26 (13–120) [8] P = 0.001 [7]
5.976
Pyridoxine responsive 257 (110–600) [12] 59 (11–180) [14] P < 0.001 [10]
6.166
RMD patients 145 (56–482) [11] 42 (7–95) [14] P = 0.006 [11]
3.433