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Table 2 Plasma total homocysteine concentrations (tHcy) before and during treatment (i.e. at the time of the survey)

From: Homocystinuria patient and caregiver survey: experiences of diagnosis and patient satisfaction

 

tHcy (µmol/l) before treatment median (range) [n]

tHcy (µmol/l) at survey median (range) [n]

Statistical significance of difference [pairwise comparisons n] t-values

All CBS-deficient patients

257 (50–640) [44]

50 (6–310) [61]

P < 0.001 [37]

10.804

Pyridoxine nonresponsive

200 (50–640) [20]

52 (6–310) [34]

P < 0.001 [15]

6.837

Partially pyridoxine responsive

300 (99–412) [7]

26 (13–120) [8]

P = 0.001 [7]

5.976

Pyridoxine responsive

257 (110–600) [12]

59 (11–180) [14]

P < 0.001 [10]

6.166

RMD patients

145 (56–482) [11]

42 (7–95) [14]

P = 0.006 [11]

3.433