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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: Facioscapulohumeral muscular dystrophy: genetics, gene activation and downstream signalling with regard to recent therapeutic approaches: an update

Fig. 1

Overview of affected muscles in FSHD. The symptoms tend to start at the upper half of the body and then spread to lower body parts involving the pelvic girdle and the leg muscles. There is a high degree of clinical variability in disease severity and affected muscles are generally involved asymmetrically regarding the left–right body axis. In some cases, patients with foot drop can be supported by ankle–foot orthotics (AFOs) and knee-ankle–foot orthotics (KAFOs) [236]. Surgery to attach the scapula to the ribcage can enhance arm motion or alleviate pain [237,238,239]

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172