Table 1 Red blood cell proteins influenced by hydroxyurea
Protein category | Proteins |
|---|---|
Antioxidants | Catalase Thioredoxin peroxidase Flavin reductase Peroxiredoxin-2 isoform |
Oxidoreductase | Aldehyde dehydrogenase |
Protein repair and degradation | Chaperonin containing TCP1 subunits Proteasome |
Membrane structure | p55 |
Cytoskeletal | Anion exchanger band 3 Actin Stomatin Ankyrin Protein 4.1 Tropomodulin |
Glycolytic enzymes | Glyceraldehydes-3-phosphate dehydrogenase Fructose-bisphosphate aldolase |
Reticulocyte membrane receptors | Alpha 4 beta 1-integrin CD36 |
Mature RBC membrane receptors | CD47 CD147 |
Other | Carbonic anhydrase |