Potential clinical utility of MUC5B und TOLLIP single nucleotide polymorphisms (SNPs) in the management of patients with IPF

Table 3 Univariate and multivariate Cox proportional hazard model evaluating predictors of death or lung transplantation

Variables	β	HR	(95% CI)	p value
Univariate analysis
Age at diagnosis (continuous)	0.030	1.030	0.976–1.088	0.282
Gender (male)	0.393	1.481	0.583–3.764	0.409
Smoking history (smoker)	0.543	1.721	0.672–4.404	0.258
CCI** (> 3)	− 0.178	0.837	0.280–2.498	0.749
BMI (continuous)	0.068	1.070	0.996–1.149	0.064
FVC % pred (continuous)	− 0.006	0.994	0.980–1.008	0.406
PaO₂ mmHg (continuous)	0.103	1.108	0.989–1.241	0.076
DLco % pred (continuous)	0.006	0.966	0.942–0.990	0.006
Antifibrotic treatment (yes)	0.549	1.332	0.648–3.136	0.074
MUC5B (T allele)	− 0.615	0.541	0.069–4.250	0.559
TOLLIP rs5743890 (C/T genotype)	0.799	2.224	1.151–4.297	0.017
TOLLIP rs3750920 (T allele)	− 0.267	0.773	0.325–1.837	0.560
Multivariate analysis*
TOLLIP rs5743890 (C/T genotype)	1.234	3.434	1.360–8.671	0.009
DLco (continuous)	− 0.071	0.931	0.898–0.966	0.001

*Model obtained by using backward conditional stepwise regression through 7 steps, including age, gender, smoking status, BMI, FVC, DLco and PaO2 as covariates
**Charlson Comorbidity Index

ISSN: 1750-1172