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Table 2 Genotype and allele distribution of the SNP rs35705950 of MUC5B, rs5743890 and rs3750920 of TOLLIP for IPF and HC subjects

From: Potential clinical utility of MUC5B und TOLLIP single nucleotide polymorphisms (SNPs) in the management of patients with IPF

Group

MUC5B rs35705950

p

Genotype

Allele

G/G (%)

G/T (%)

T/T (%)

G (%)

T (%)

HC

42 (84)

7 (14)

1 (2)

91 (91)

9 (9)

 

HWE

  

0.304*

  

 < 0.001**

IPF

23 (37)

35 (56)

4 (6)

81 (65)

43 (35)

 

HWE

  

0.052*

   

Group

TOLLIP rs5743890

P

Genotype

Allele

T/T (%)

C/T (%)

C/C (%)

T (%)

C (%)

HC

40 (80)

9 (18)

1 (2)

89 (89)

11 (11)

 

HWE

  

0.568*

  

0.999**

IPF

48 (77)

14 (23)

0 (0)

110 (89)

14 (11)

 

HWE

  

0.316*

   

Group

TOLLIP rs3750920

P

Genotype

Allele

C/C (%)

C/T (%)

T/T (%)

C (%)

T (%)

HC

14 (28)

26 (52)

10 (20)

54 (54)

46 (46)

 

HWE

  

0.741*

  

0.999**

IPF

15 (24)

37 (60)

10 (16)

67 (54)

57 (45)

 

HWE

  

0.112*

   
  1. *p value of either chi-square test or Fisher’s exact test is indicated to determine the deviation from HWE
  2. **Fisher’s exact test