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Table 2 The effects of every single lipoprotein apheresis therapy during the monitored interval of 15 years on selected parameters of lipid metabolism, inflammatory biomarkers, and soluble endoglin

From: Monitoring of up to 15 years effects of lipoprotein apheresis on lipids, biomarkers of inflammation, and soluble endoglin in familial hypercholesterolemia patients

Parameter

HeFH (n = 10)

HoFH (n = 4)

Lipids, mmol/l

Before LA

After LA

Decrease, n (%) patients

Before LA

After LA

Decrease, n (%) patients

TC

5.69 (1.16)

1.93 (0.59)***

10 (100)

7.09 (2.15)

1.95 (0.66)***

4 (100)

LDLC

3.57 (1.19)

0.75 (0.54)***

10 (100)

5.13 (1.87)

0.85 (0.94)***

4 (100)

HDLC

1.34 (0.65)

0.91 (0.33)***

10 (100)

1.51 (0.72)

1.15 (0.39)***

4 (100)

ApoB

1.11 (0.28)

0.28 (0.22)***

10 (100)

1.22 (0.50)

0.18 (0.17)***

4 (100)

Endoglin, ng/mL

6.45 (1.85)

5.56 (1.75)***

8 (80)

6.22 (1.73)

4.85 (1.80)***

3 (75)

CD40L, pg/mL

5323 (2059)

5367 (3093)

4 (40)

5177 (1585)

4239 (1892)

2 (50)

hsCRP, mg/L

2.84 (1.51)

2.39 (1.38)

6 (60)

2.21 (1.36)

1.82 (1.27)

3 (75)

MCP-1, pg/mL

321.8 (99.2)

274.5 (86.1)

6 (60)

265.6 (71.0)

221.4 (68.2)

3 (75)

sP-selectin, ng/mL

148.1 (50.7)

131.7 (53.8)*

7 (70)

145.6 (70.6)

154.3 (212.2)

3 (75)

  1. Data shows the level of parameters before and after each procedure during the time patients underwent LA and the percentage of cases (patients) where change was significant
  2. *p < 0.05, ***p < 0.001