Table 1 Comparison of lipid profile, markers of LDL quality and HDL functionality, and markers of inflammation between patients with Niemann–Pick disease type B and healthy controls at baseline
Controls (n = 15) | Niemann–Pick Disease type B (n = 5) | P value | |
|---|---|---|---|
Age | 35.3 ± 16.3 | 32.6 ± 9.4 | 0.363 |
Total cholesterol (mmol/l) | 5.1 ± 1.5 | 4.5 ± 0.8 | 0.426 |
Triglyceride (mmol/l) | 1.0 ± 0.3 | 2.2 ± 1.5 | 0.003 |
HDL-C (mmol/l) | 1.29 ± 0.27 | 0.79 ± 0.28 | 0.002 |
LDL-C (mmol/l) | 3.4 ± 1.3 | 2.9 ± 0.5 | 0.469 |
ApoA1 (g/l) | 1.39 ± 0.17 | 0.84 ± 0.25 | < 0.001 |
ApoB100 (g/l) | 0.72 ± 0.26 | 0.94 ± 0.21 | 0.098 |
ApoB48 (µg/ml) | 61.0 ± 12.3 | 89.8 ± 11.9 | < 0.001 |
sdLDL-C (mg/dl) | 29.0 ± 18.5 | 44.7 ± 18.2 | 0.118 |
oxLDL (ng/ml) | 88.2 ± 21.4 | 131.1 ± 22.8 | 0.001 |
PCSK9 mass (ng/ml) | 366.8 ± 127.8 | 599.0 ± 237.6 | 0.011 |
TNF-α (pg/ml) | 27.7 ± 8.8 | 76.0 ± 10.7 | < 0.001 |
PON1 activity (nmol/ml/min) | 158.1 ± 128.8 | 98.5 ± 79.0 | 0.347 |
Cholesterol efflux capacity (%) | 13.1 ± 1.4 | 11.9 ± 1.4 | 0.150 |