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Table 3 Comparison of biochemical variables of A-T patients and controls

From: Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

Variables

Units

A-T patients

(n = 22)

Controls

(n = 18)

P-value

Lipid status biomarkers

   

Total cholesterol

mg/dL

188.5 (168.0–228.0)

164.0 (124.0–172.0)

0.005

LDL-c

mg/dL

124.4 (105.4–166.0)

89.5 (67.0–105.6)

 < 0.001

Triglycerides

mg/dL

90.5 (66.0–115.0)

77.5 (63.0–94.0)

0.231

HDL-c

mg/dL

47.5 (42.0–61.4)

46.0 (35.0–56.0)

0.549

Non-HDL-c

mg/dL

136.5 (120.0–182.0)

108.0 (79.0–125.0)

0.001

VLDL-c

mg/dL

18.1 (13.2–23.0)

15.5 (12.6–18.8)

0.231

Remnant cholesterol

mg/dL

18.2 (13.2–23.0)

15.6 (12.6–18.8)

0.221

Oxidized LDL

mg/dL

72.6 (42.6–137.0)

25.8 (21.1–40.7)

 < 0.001

Apolipoprotein A-1

mg/dL

99.0 (87.0–117.0)

122.0 (92.0–138.0)

0.070

Apoliprotein B

mg/dL

109.5 (96.0–138.0)

91.0 (78.0–101.0)

0.002

Apoliprotein B/Apoliprotein A-1

 

1.1 (0.7–1.5)

0.7 (0.5–0.8)

0.001

Total cholesterol/HDL-c

 

4.0 (3.0–5.0)

3.0 (3.0–4.0)

0.080

LDL-c/Apoliprotein B

 

1.1 (1.0–1.2)

1.1 (0.9–1.1)

0.549

LDL-c/ HDL-c

 

2.5 (2.0–4.0)

2.0 (1.0–2.0)

0.021

Triglycerides/HDL-c

 

2.0 (1.0–3.0)

1.0 (1.0–3.0)

0.279

Apoliprotein A-1/HDL-c

 

1.9 (1.8–2.1)

2.5 (2.2–2.7)

0.008

Oxidative stress and inflammatory biomarkers

  

Glutathione peroxidase

U/L

7300 (6683–8267)

8686 (7967–9449)

0.005

Selenium

µg/L

47.6 (43.2–57.0)

54.6 (45.2–62.6)

0.242

Malondialdehyde

nmol/mL

3.8 (3.0–4.0)

2.8 (2.4–3.6)

0.029

C-reactive protein

mg/L

1.0 (0.3–9.8)

0.65 (0.3–1.6)

0.116

Adiponectin

mg/dL

156.9 (125.5–234.6)

180.4 (173.1–183.9)

0.355

Glucose metabolism biomarkers

   

Blood glucose

mg/dL

85 (77.0–88.5)

83.0 (77.2–90.0)

0.810

Insulin

uU/mL

6.1 (2.5–11.6)

7.4 (3.6–10.6)

0.870

HOMA-IR

 

1.1 (0.4–3.4)

1.2 (0.7–2.0)

0.891

Liver enzymes

   

Aspartate aminotransferase

U/L

31.0 (25.0–47.0)

17.0 (14.0–19.0)

 < 0.001

Alanine aminotransferase

U/L

21.0 (13.0–32.0)

9.5 (9.0–13.0)

 < 0.001

Gamma-glutamyl transpeptidase

U/L

27.7 (14.3–66.7)

14.6 (10.1–17.4)

0.011

  1. Laboratory variables in control group (N = 14)
  2. Significance level of Mann–Whitney test, Median (IQ25-75)
  3. LDL-c, low density lipoprotein cholesterol; HDL-c, high density lipoprotein cholesterol; VLDL-c, very low density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172