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Table 3 Comparison of biochemical variables of A-T patients and controls

From: Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

Variables Units A-T patients
(n = 22)
Controls
(n = 18)
P-value
Lipid status biomarkers    
Total cholesterol mg/dL 188.5 (168.0–228.0) 164.0 (124.0–172.0) 0.005
LDL-c mg/dL 124.4 (105.4–166.0) 89.5 (67.0–105.6)  < 0.001
Triglycerides mg/dL 90.5 (66.0–115.0) 77.5 (63.0–94.0) 0.231
HDL-c mg/dL 47.5 (42.0–61.4) 46.0 (35.0–56.0) 0.549
Non-HDL-c mg/dL 136.5 (120.0–182.0) 108.0 (79.0–125.0) 0.001
VLDL-c mg/dL 18.1 (13.2–23.0) 15.5 (12.6–18.8) 0.231
Remnant cholesterol mg/dL 18.2 (13.2–23.0) 15.6 (12.6–18.8) 0.221
Oxidized LDL mg/dL 72.6 (42.6–137.0) 25.8 (21.1–40.7)  < 0.001
Apolipoprotein A-1 mg/dL 99.0 (87.0–117.0) 122.0 (92.0–138.0) 0.070
Apoliprotein B mg/dL 109.5 (96.0–138.0) 91.0 (78.0–101.0) 0.002
Apoliprotein B/Apoliprotein A-1   1.1 (0.7–1.5) 0.7 (0.5–0.8) 0.001
Total cholesterol/HDL-c   4.0 (3.0–5.0) 3.0 (3.0–4.0) 0.080
LDL-c/Apoliprotein B   1.1 (1.0–1.2) 1.1 (0.9–1.1) 0.549
LDL-c/ HDL-c   2.5 (2.0–4.0) 2.0 (1.0–2.0) 0.021
Triglycerides/HDL-c   2.0 (1.0–3.0) 1.0 (1.0–3.0) 0.279
Apoliprotein A-1/HDL-c   1.9 (1.8–2.1) 2.5 (2.2–2.7) 0.008
Oxidative stress and inflammatory biomarkers   
Glutathione peroxidase U/L 7300 (6683–8267) 8686 (7967–9449) 0.005
Selenium µg/L 47.6 (43.2–57.0) 54.6 (45.2–62.6) 0.242
Malondialdehyde nmol/mL 3.8 (3.0–4.0) 2.8 (2.4–3.6) 0.029
C-reactive protein mg/L 1.0 (0.3–9.8) 0.65 (0.3–1.6) 0.116
Adiponectin mg/dL 156.9 (125.5–234.6) 180.4 (173.1–183.9) 0.355
Glucose metabolism biomarkers    
Blood glucose mg/dL 85 (77.0–88.5) 83.0 (77.2–90.0) 0.810
Insulin uU/mL 6.1 (2.5–11.6) 7.4 (3.6–10.6) 0.870
HOMA-IR   1.1 (0.4–3.4) 1.2 (0.7–2.0) 0.891
Liver enzymes    
Aspartate aminotransferase U/L 31.0 (25.0–47.0) 17.0 (14.0–19.0)  < 0.001
Alanine aminotransferase U/L 21.0 (13.0–32.0) 9.5 (9.0–13.0)  < 0.001
Gamma-glutamyl transpeptidase U/L 27.7 (14.3–66.7) 14.6 (10.1–17.4) 0.011
  1. Laboratory variables in control group (N = 14)
  2. Significance level of Mann–Whitney test, Median (IQ25-75)
  3. LDL-c, low density lipoprotein cholesterol; HDL-c, high density lipoprotein cholesterol; VLDL-c, very low density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance