Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

Table 2 Comparison of the variables: demographic, anthropometric, lipid status biomarkers, selenium, glutathione peroxidase activity, malondialdehyde, C-reactive protein of A-T patients and controls

	Variables	A-T patients (n = 22)	Controls (n = 18)	P-value
Age	Years	12.2 (8.5–20.9)	15.8 (9.8–22.8)	0.615^a
Gender	Male	16 (72.7%)	13 (72.2%)	0.972^b
Prepubertal	Yes	6 (27.3%)	3 (16.7%)	0.506^b
Body mass index (kg/m²)	Underweight	9 (40.9%)	2 (11.1%)	0.146^b
	Normal	11 (50.0%)	14 (77.8%)
	Overweight	2 (9.1%)	2 (11.1%)
Waist circumference	cm	60.0 (53.0–64.0)	68.8 (61.0–79.0)	0.004^a
Lean body mass	kg	24.8 (20.2–29.8)	41.8 (31.0–50.4)	0.001^a
Dyslipidemia	Yes	14 (63.6%)	11 (78.6%)	0.467^b
Lipid profile	High CT	13 (59.1%)	4 (28.6%)	0.097^b
	High LDL-c	12 (54.4%)	1 (7.1%)	0.005^b
	Low HDL-c	4 (18.2%)	6 (42.8%)	0.140^b
	High triglycerides	5 (22.7%)	1 (7.1%)	0.370^b
	High non-HDL-c	13 (59.1%)	2 (14.3%)	0.014^b
Glycemia	Elevate (> 100 mg/dL)	1 (4.5%)	1 (7.1%)	0.633^b
HOMA-IR	Elevate (> 3.16)	6 (27.3%)	2 (14.3%)	0.441^b
Selenium	Adequate (> 46 μg/L)	13 (59.1%)	11 (78.6%)	0.292^b
Glutathione peroxidase	Adequate (> 4171 U/L)	20 (90.9%)	11 (78.6%)	0.357^b
Malondialdehyde	High (≥ 3.46 nmol/mL)	16 (72.7%)	5 (35.7%)	0.041^b
C-reactive protein	High (> 3 mg/L)	8 (36.4%)	1 (7.1%)	0.062^b

Laboratory variables in control group (N = 14)
Significance level of: ^aMann-Whitney test, Median (IQ_25-75). ^bChi-square test, N (%)
CT, total cholesterol; LDL-c, low density lipoprotein cholesterol; HDL-c, high density lipoprotein cholesterol; NHDL-c, Non-HDL-c; HOMA-IR, homeostasis model assessment of insulin resistance

ISSN: 1750-1172