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Table 1 Clinical characteristics of 59 pLCNEC patients

From: Survival outcomes of surgery in patients with pulmonary large-cell neuroendocrine carcinoma: a retrospective single-institution analysis and literature review

Variables

Value (N = 59)

Sex ratio (male:female)

48:11

Median age (years)

62 (38–79)

Median disease duration (months)

2 (0.5–18)

Smoking/non-smoking

43:16

Family history of malignancy

4 (6.8%)

Initial symptoms

 

 Asymptomatic

25 (42.4%)

 Cough

16 (27.1%)

 Bloody sputum

12 (20.3%)

 Chest and back pain

4 (6.8%)

 Fever

3 (5.1%)

 Chest tightness

4 (6.8%)

Median tumour size (cm)

3.0 (1.0–12.0)

Peripheral type/central type

36:23

Scope of surgical resection

 

 Lobectomy

41 (69.5%)

 Combined lobectomy

13 (22.0%)

 Sublobar resection

5 (8.5%)

Surgical approach

 

 VATS

23 (39.0%)

 PLT

36 (61.0%)

Pathological type (pure:mixed)

51:8

Postoperative TNM stage

 

 I

25 (42.4%)

 II

12 (20.3%)

 III

15 (25.4%)

 IV

7 (11.9%)

 Median Ki-67 index

72.5 (40–95)

AT

 

 nd

15 (25.4%)

 Ct

35 (59.3%)

 Rt

1 (1.7%)

 Ct and Rt

8 (13.6%)

Perioperative complications

 

 Pulmonary infection

2 (3.4%)

 Respiratory failure

1 (1.7%)

 Acute cerebral infarction

2 (3.4%)

 Air leakage

1 (1.7%)

 Arrhythmia

1 (1.7%)

  1. VATS video-assisted thoracic surgery, PLT posterolateral thoracotomy, nd not done, AT adjuvant therapy, Ct chemotherapy, Rt radiotherapy