Fig. 2
From: Impact of pediatric hypophosphatasia on behavioral health and quality of life
Symptoms of depression and ADHD were associated with weaker development of adaptive skills in pediatric patients with HPP. VABS-3 scores are standardized with an average score of 100 ± 15, with higher scores indicating better functioning. BASC-3 T-scores are standardized with an average score of 50 ± 10, with scores ≥ 60 indicating mild to moderate mood difficulties, and scores ≥ 70 indicating severe symptoms of depression. Children were classified as having clinical ADHD symptoms if ratings on the ADHD-RS met DSM-5 symptom criteria and they had an elevated scores (≥ 60) on the BASC-3 Inattention or Hyperactivity scales