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Table 6 Frequency of ranking domain in top 5 by age of patient's first symptom

From: Validation of the 5-domain Niemann-Pick type C Clinical Severity Scale

n (%)

 < 3 months

(n = 8)

3–23 months

(n = 7)

2–5 years

(n = 7)

6–15 years

(n = 14)

 > 15 years

(n = 13)

Overall

(n = 49)

Ambulation

8 (100.0)

4 (57.1)

6 (85.7)

12 (85.7)

11 (84.6)

41 (83.7)

Fine motor skills

4 (50.0)

2 (28.6)

4 (57.1)

4 (28.6)

8 (61.5)

22 (44.9)

Speech

3 (37.5)

4 (57.1)

7 (100.0)

8 (57.1)

10 (76.9)

32 (65.3)

Swallow

5 (62.5)

6 (85.7)

6 (85.7)

11 (78.6)

7 (53.8)

35 (71.4)

Cognition

6 (75.0)

4 (57.1)

2 (28.6)

6 (42.9)

5 (38.5)

23 (46.9)