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Table 6 Frequency of ranking domain in top 5 by age of patient's first symptom

From: Validation of the 5-domain Niemann-Pick type C Clinical Severity Scale

n (%)  < 3 months
(n = 8)
3–23 months
(n = 7)
2–5 years
(n = 7)
6–15 years
(n = 14)
 > 15 years
(n = 13)
Overall
(n = 49)
Ambulation 8 (100.0) 4 (57.1) 6 (85.7) 12 (85.7) 11 (84.6) 41 (83.7)
Fine motor skills 4 (50.0) 2 (28.6) 4 (57.1) 4 (28.6) 8 (61.5) 22 (44.9)
Speech 3 (37.5) 4 (57.1) 7 (100.0) 8 (57.1) 10 (76.9) 32 (65.3)
Swallow 5 (62.5) 6 (85.7) 6 (85.7) 11 (78.6) 7 (53.8) 35 (71.4)
Cognition 6 (75.0) 4 (57.1) 2 (28.6) 6 (42.9) 5 (38.5) 23 (46.9)