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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy

Fig. 2

Real-time respirometry in fibroblasts of LHON patients. Respiratory chain activity was assessed by Real-Time respirometry (Seahorse measurement) in primary fibroblasts derived from a a healthy control, b a patient carrying the m.3460G>A mutation, and c a patient carrying the m.14484T>C mutation. Cells were incubated in the presence of DMSO or STM 150 µM for 3 h before the measurement (Mean, SEM, n = 6). OCR, oxygen consumption rate. d Extracellular acidification rates (ECAR) of primary fibroblasts (as in panels a–c) after uncoupling respiration with FCCP (Mean, SEM, n = 6)

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172