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Table 4 Proteins associated with cellular trafficking and autophagy in human MLIV brain

From: Proteomics analysis of a human brain sample from a mucolipidosis type IV patient reveals pathophysiological pathways

Protein

CB

CRB

Ratio (MLIV/Con)

Cellular trafficking

TMEM106B

1.27

3.2

GGA3

−

0.57

GORS2

−

0.91

TRAPPC2L

−

−

TRAPPC11

−

1.03

TRAPPC6B

−

1.06

TRAPPC9

−

1.11

SYT11

−

−

SNX9

−

1.48

SNAP29

−

0.78

RAB9A

−

 + 

RAB9B

0.09

−

VAMP7

n.d

−

VPS41

0.79

2.11

VTI1B

0.63

0.65

WDR81

−

 + 

Autophagy

ACBD5

 + 

1.33

ATG3

4.81

2.04

DCN

2.31

 + 

MAP1LC3A

2.23

3.09

MAP1LC3B/21

 + 

 + 

SQSTM1

1.15

2.55

ATG4B

−

n.d

ATG5

−

0.9

ATG7

−

1.51

ATG16L1

−

−

ATG2B

−

0.68

ATG13

−

−

WIPI2

−

0.71

SMCR8

−

−

  1. 23 proteins were detected related to cellular trafficking and 31 proteins related to autophagy (27 had > 1 unique peptide). The proteins listed in the Table are those that differ between the control and MLIV. See Table 1 for explanation of the symbols
  2. 1 The detected peptides cannot distinguish between MAP1LC3B or MAP1LC3B2