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Table 2 Proteins related to lipid metabolism in human brain and CSF

From: Proteomics analysis of a human brain sample from a mucolipidosis type IV patient reveals pathophysiological pathways

Protein

CB

CRB

CSF

Ratio (MLIV/Con)

  

S1PR1

n.d

 + 

n.d

S1PR5

n.d

 + 

n.d

CERS1

1.71

2.01

n.d

KDSR

2.93

4.35

n.d

GALC

 + 

2.97

n.d

SPHK2

 + 

1.03

n.d

MVD

2.84

1.31

0.68

MVK

2.08

0.93

n.d

MSMO1

 + 

0.91

n.d

SEC14L2

3.54

1.51

3.18

SGPP1

n.d

−

n.d

SMPD3

−

0.71

n.d

GBA2

−

0.61

n.d

PLIN3

0.86

2.72

1.46

PLIN4

 + 

7.41

n.d

APOA1

0.09

0.44

0.15

APOA2

−

1.31

0.20

APOA4

0.53

0.87

0.45

APOB

0.62

n.d

0.20

APOC3

−

−

−

APOD

5.21

10.7

0.26

APOE

0.36

1.12

1.27

APOH

0.81

 + 

0.06

  1. A total of 18 proteins related to SL metabolism, 6 related to cholesterol, 4 related to ganglioside metabolism, 3 related to lipid droplet and 12 related to apolipoprotein metabolism were detected. The proteins listed in the Table are those that differ between the control and MLIV in one or other tissue. See Table 1 for explanation of the symbols