Fig.1

Up- and down-regulated pathways in post mortem MLIV brain and in 7-month-old Mcoln1^−/− mouse brain. Pathway analysis of up-(a, b)-and down-regulated c, d proteins (ratio of MLIV/ control > 1.5) in the cerebellum (CB) and cerebrum (CRB). e Pathway analysis of DEGs (fold-change > 1.5, p adjusted < 0.05) in 7 month-old Mcoln1^−/− mice (n = 5) versus Mcoln1^± mice (n = 5). The number of identified proteins out of total proteins associated with each pathway are shown