Structural alteration of lung parenchyma in patients with NF1: a phenotyping study using multidetector computed tomography (MDCT)

Table 4 Comparison of the clinical and pulmonary findings between patients with and without MPNST

	MPNST n = 30	No MPNST n = 41	p value^a
Female gender	12 (40)	28 (68)	< 0.05
Age	36 ± 13	32 ± 15	0.26
Current Smokers	9 (30)	8 (20)	0.46
Reticulations	10 (33)	8 (20)	0.30
Nodules	17 (57)	6 (15)	< 0.001
≤ 10	12 (40)	6 (15)	< 0.05
> 10	5 (17)	0 (0)	< 0.05
Ø Diameter (mm)	5 ± 2	4 ± 2	0.23
GGO	4 (14)	3 (7)	0.42
Consolidation	3 (11)	3 (7)	0.67
Emphysema	11 (37)	11 (27)	0.53
Centrilobular	2 (7)	3 (7)	1.0
Paraseptal	11 (37)	10 (24)	0.39
Cysts	10 (33)	15 (37)	0.97
≤ 10	8 (27)	10 (24)	0.95
> 10	2 (7)	5 (12)	0.69
Ø Diameter (mm)	8 ± 2	7 ± 4	0.59
UL	6 (20)	8 (20)	0.80
ML	1 (3)	1 (2)	1.0
LL	3 (10)	6 (15)	0.72
Thickened interlobular septa	5 (17)	5 (12)	0.73
Pleural effusion	2 (7)	1 (2)	0.57
Pulmonary metastasis	6 (21)	0 (0)	< 0.05

Data are presented as absolute numbers and frequencies (%) or as mean values ± standard deviation (SD)
^aFisher exact test or χ² test; p values < 0.05 (bold) were considered to indicate statistical significance
MPNST malignant peripheral nerve sheath tumor, GGO ground glass opacity, UL upper lobe, ML middle lobe, LL lower lobe

ISSN: 1750-1172