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Table 4 Comparison of the clinical and pulmonary findings between patients with and without MPNST

From: Structural alteration of lung parenchyma in patients with NF1: a phenotyping study using multidetector computed tomography (MDCT)

  MPNST
n = 30
No MPNST
n = 41
p valuea
Female gender 12 (40) 28 (68) < 0.05
Age 36 ± 13 32 ± 15 0.26
Current Smokers 9 (30) 8 (20) 0.46
Reticulations 10 (33) 8 (20) 0.30
Nodules 17 (57) 6 (15) < 0.001
≤ 10 12 (40) 6 (15) < 0.05
> 10 5 (17) 0 (0) < 0.05
Ø Diameter (mm) 5 ± 2 4 ± 2 0.23
GGO 4 (14) 3 (7) 0.42
Consolidation 3 (11) 3 (7) 0.67
Emphysema 11 (37) 11 (27) 0.53
 Centrilobular 2 (7) 3 (7) 1.0
 Paraseptal 11 (37) 10 (24) 0.39
Cysts 10 (33) 15 (37) 0.97
≤ 10 8 (27) 10 (24) 0.95
> 10 2 (7) 5 (12) 0.69
Ø Diameter (mm) 8 ± 2 7 ± 4 0.59
UL 6 (20) 8 (20) 0.80
ML 1 (3) 1 (2) 1.0
LL 3 (10) 6 (15) 0.72
Thickened interlobular septa 5 (17) 5 (12) 0.73
Pleural effusion 2 (7) 1 (2) 0.57
Pulmonary metastasis 6 (21) 0 (0) < 0.05
  1. Data are presented as absolute numbers and frequencies (%) or as mean values ± standard deviation (SD)
  2. aFisher exact test or χ2 test; p values < 0.05 (bold) were considered to indicate statistical significance
  3. MPNST malignant peripheral nerve sheath tumor, GGO ground glass opacity, UL upper lobe, ML middle lobe, LL lower lobe