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Table 3 Comparison of the clinical and pulmonary findings between children (< 12 years), adolescents (12–18 years) and adults (> 18 years)

From: Structural alteration of lung parenchyma in patients with NF1: a phenotyping study using multidetector computed tomography (MDCT)

  Children
(< 12 years)
n = 4
Adolescents
(12–18 years)
n = 5
Adults
(> 18 years)
n = 62
p valuea Association by Cramer’s V
Female gender 2 (50) 3 (60) 35 (56) 0.88
Age 7 ± 4* 16 ± 1* 36 ± 12 < 0.001
Current smokers 0 (0) 1 (20) 16 (26) 0.25
MPNST 0 (0) 2 (40) 28 (45) 0.10
Reticulations 1 (25) 0 (0) 17 (27) 0.49
Nodules 1 (25) 1 (20) 21 (34) 0.74
≤ 10 1 (25) 1 (20) 16 (26) 0.87
> 10 0 (0) 0 (0) 5 (8) 0.41
Max. Diameter (mm) 2 3 11 0.37  
GGO 0 (0) 0 (0) 7 (11) 0.32
Consolidation 1 (25) 0 (0) 5 (8) 0.45
Emphysema 0 (0) 1 (20) 21 (34) 0.13
 Centrilobular 0 (0) 0 (0) 5 (8) 0.41
 Paraseptal 0 (0) 1 (20) 20 (34) 0.15
Cysts 0 (0) 0 (0) 25 (40) < 0.05 0.281
≤ 10 0 (0) 0 (0) 18 (29) 0.08
> 10 0 (0) 0 (0) 7 (11) 0.32
Max. Diameter (mm) 0 0 6 ± 3
UL 0 (0) 0 (0) 14 (23) 0.13
ML 0 (0) 0 (0) 2 (3) 0.61
LL 0 (0) 0 (0) 9 (15) 0.25
Thickened interlobular septa 0 (0) 0 (0) 10 (16) 0.22
Pleural effusion 0 (0) 0 (0) 3 (5) 0.53
Pulmonary metastasis 0 (0) 1 (20) 5 (8) 0.93
  1. Data are presented as absolute numbers and frequencies (%) or as mean values ± standard deviation (SD)
  2. aFisher exact test; Cochran-Armitage test for trend: p values < 0.05 (bold) were considered to indicate statistical significance. *p values < 0.017 versus Adults, applying Bonferroni correction for multiple comparisons across the three groups
  3. MPNST malignant peripheral nerve sheath tumor, GGO ground glass opacity, UL upper lobe, ML middle lobe, LL lower lobe