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Table 2 Comparison of the clinical and pulmonary findings between current smokers, previous smokers and never smokers

From: Structural alteration of lung parenchyma in patients with NF1: a phenotyping study using multidetector computed tomography (MDCT)

 

Current smokers

n = 17

Previous smokersa

n = 8

Never smokers

n = 46

p value

Association by Cramer’s V

Female gender

5 (29)

4 (50)

31 (67)

< 0.05

0.323

Age

31 ± 11

42 ± 7

35 ± 16

0.08

–

MPNST

9 (53)

6 (75)

15 (33)

< 0.05

0.292

Reticulations

4 (24)

2 (25)

12 (26)

0.98

–

Nodules

8 (47)

2 (25)

13 (28)

0.33

–

≤ 10

6 (35)

1 (12)

11 (24)

0.44

–

> 10

2 (12)

1 (12)

2 (4)

0.48

–

Max. diameter (mm)

6 ± 6

6 ± 2

5 ± 2

0.69

–

GGO

3 (18)

0 (0)

4 (9)

0.35

–

Consolidation

1 (6)

0 (0)

5 (11)

0.54

–

Emphysema

8 (47)

2 (25)

12 (26)

0.26

–

 Centrilobular

4 (24)

0 (0)

1 (2)

< 0.05

0.363

 Paraseptal

8 (47)

2 (25)

11 (24)

0.19

–

Cysts

7 (41)

2 (25)

16 (35)

0.73

–

≤ 10

3 (18)

2 (25)

13 (28)

0.69

–

> 10

4 (24)

0 (0)

3 (7)

0.08

–

Max. diameter (mm)

9 ± 4

8 ± 2

6 ± 2

0.29

–

UL

7 (41)

0 (0)

7 (15)

< 0.05

0.325

ML

0 (0)

0 (0)

2 (4)

0.57

–

LL

0 (0)

2 (25)

7 (15)

< 0.05

0.310

Thickened interlobular septa

2 (12)

2 (25)

6 (13)

0.64

–

Pleural effusion

0 (0)

1 (12)

2 (4)

0.35

–

Pulmonary metastasis

4 (24)

1 (12)

1 (2)

< 0.05

0.325

  1. Data are presented as absolute numbers and frequencies (%) or as mean values ± standard deviation (SD)
  2. aSmoking cessation > 5 years ago
  3. Cochran-Armitage test for trend p values < 0.05 (bold) were considered to indicate statistical significance
  4. MPNST malignant peripheral nerve sheath tumor, GGO ground glass opacity, UL upper lobe, ML middle lobe, LL Lower lobe