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Table 2 Comparison of the clinical and pulmonary findings between current smokers, previous smokers and never smokers

From: Structural alteration of lung parenchyma in patients with NF1: a phenotyping study using multidetector computed tomography (MDCT)

  Current smokers
n = 17
Previous smokersa
n = 8
Never smokers
n = 46
p value Association by Cramer’s V
Female gender 5 (29) 4 (50) 31 (67) < 0.05 0.323
Age 31 ± 11 42 ± 7 35 ± 16 0.08
MPNST 9 (53) 6 (75) 15 (33) < 0.05 0.292
Reticulations 4 (24) 2 (25) 12 (26) 0.98
Nodules 8 (47) 2 (25) 13 (28) 0.33
≤ 10 6 (35) 1 (12) 11 (24) 0.44
> 10 2 (12) 1 (12) 2 (4) 0.48
Max. diameter (mm) 6 ± 6 6 ± 2 5 ± 2 0.69
GGO 3 (18) 0 (0) 4 (9) 0.35
Consolidation 1 (6) 0 (0) 5 (11) 0.54
Emphysema 8 (47) 2 (25) 12 (26) 0.26
 Centrilobular 4 (24) 0 (0) 1 (2) < 0.05 0.363
 Paraseptal 8 (47) 2 (25) 11 (24) 0.19
Cysts 7 (41) 2 (25) 16 (35) 0.73
≤ 10 3 (18) 2 (25) 13 (28) 0.69
> 10 4 (24) 0 (0) 3 (7) 0.08
Max. diameter (mm) 9 ± 4 8 ± 2 6 ± 2 0.29
UL 7 (41) 0 (0) 7 (15) < 0.05 0.325
ML 0 (0) 0 (0) 2 (4) 0.57
LL 0 (0) 2 (25) 7 (15) < 0.05 0.310
Thickened interlobular septa 2 (12) 2 (25) 6 (13) 0.64
Pleural effusion 0 (0) 1 (12) 2 (4) 0.35
Pulmonary metastasis 4 (24) 1 (12) 1 (2) < 0.05 0.325
  1. Data are presented as absolute numbers and frequencies (%) or as mean values ± standard deviation (SD)
  2. aSmoking cessation > 5 years ago
  3. Cochran-Armitage test for trend p values < 0.05 (bold) were considered to indicate statistical significance
  4. MPNST malignant peripheral nerve sheath tumor, GGO ground glass opacity, UL upper lobe, ML middle lobe, LL Lower lobe