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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: A recurrent ABCC2 p.G693R mutation resulting in loss of function of MRP2 and hyperbilirubinemia in Dubin-Johnson syndrome in China

Fig. 3

The MRP2 p.G693R mutant with flag tag showed mislocalization in Huh-7 cells in vitro. a Immunofluorescence analysis of MRP2 fusion protein with N-terminal flag tag in Huh-7 cells confirmed MRP2 expression in wild-type and p.G693R mutant MRP2 plasmids. b Immunofluorescence analysis of F-actin and MRP2 expression in Huh-7 cells showed wild-type MRP2 predominantly localized to the cell surface and cytoplasm, while MRP2 p.G693R mutant was mostly retained at the cytoplasm

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172