Skip to main content

Table 4 Gender differences in HHT severity according to HHT1 or HHT2 subtypes

From: Gender differences in hereditary hemorrhagic telangiectasia severity

  HHT 1 (n = 80) P value HHT2 (n = 75) P value
  Female (n = 49) Male (n = 31) Female (n = 42) Male (n = 33)  
ESS 2.82 ± 1.95 2.81 ± 1.95 0.977 3.67 ± 1.96 3.81 ± 1.80 0.744
 ESS Control 2.12 ± 1.59 2.15 ± 1.89 0.937 2.25 ± 1.65 2.76 ± 1.50 0.238
 ESS ≥ 4 16 (32.7%) 7 (22.6%) 0.332 20 (47.6%) 14 (42.4%) 0.669
 ESS ≥ 7 1 (2%) 1 (3.2%) 1.000 2 (4.8%) 1 (3.1%) 1.000
Simple Clinical Scoring Index 2.97 ± 1.08 1.62 ± 1.04 < 0.001 3.64 ± 1.25 1.93 ± 1.23 < 0.001
 Low 20 (40.8%) 21 (67.8%) 0.002 6 (14.3%) 21 (63.6%) < 0.001
 Intermediate 29 (59.2%) 6 (19.4%) 0.002 26 (61.9%) 10 (30.3%) 0.003
 High 0 0   5 (11.9%) 0 0.058
HHT-score 2.24 ± 0.99 2.13 ± 0.86 0.599 2.35 ± 1.05 1.93 ± 0.82 0.058
 Mild 30 (61.2%) 21 (67.7%) 0.429 28 (66.7%) 25 (75.8%) 0.391
 Moderate 19 (38.8%) 9 (29%) 0.429 11 (26.2%) 8 (24.2%) 0.847
 Severe 0 0   3 (7.1%) 0 0.251
Invasive treatment,
 Pulmonary embolization 17 (34.7%) 12 (38.7%) 0.716 5 (11.9%) 0 0.063
 Brain embolization 1 (2%) 0 1.000 1 (2.4%) 0 1.000
 Liver  transplantation 0 0   1 (2.4%) 0 1.000
 Young surgery 0 0   1 (2.4%) 0 1.000
Anyone of the above 18 (36.7%) 12 (38.7%) 0.859 7 (16.7%) 0 0.016
Adverse outcomes,
 Hemoglobin < 8 g/dL or RBC transfusion 8 (16.3%) 5 (16.1%) 1.000 16 (38.1%) 11 (33.3%) 0.452
 ED visit 8 (16.3%) 11 (35.5%) 0.050 12 (28.6%) 16 (48.5%) 0.077
 Hospital admission 6 (12.2%) 8 (25.8%) 0.120 8 (19%) 3 (9.1%) 0.328
 Mortality 0 0   2 (4.8%) 1 (3%) 1.000
 Anyone of the above 17 (34.7%) 13 (41.9%) 0.515 22 (52.4%) 16 (48.5%) 0.738
  1. Abbreviations: EES Epistaxis Severity Score, RBC red blood cell, ED emergency department