Skip to main content

Table 4 Gender differences in HHT severity according to HHT1 or HHT2 subtypes

From: Gender differences in hereditary hemorrhagic telangiectasia severity

 

HHT 1 (n = 80)

P value

HHT2 (n = 75)

P value

 

Female (n = 49)

Male (n = 31)

Female (n = 42)

Male (n = 33)

 

ESS

2.82 ± 1.95

2.81 ± 1.95

0.977

3.67 ± 1.96

3.81 ± 1.80

0.744

 ESS Control

2.12 ± 1.59

2.15 ± 1.89

0.937

2.25 ± 1.65

2.76 ± 1.50

0.238

 ESS ≥ 4

16 (32.7%)

7 (22.6%)

0.332

20 (47.6%)

14 (42.4%)

0.669

 ESS ≥ 7

1 (2%)

1 (3.2%)

1.000

2 (4.8%)

1 (3.1%)

1.000

Simple Clinical Scoring Index

2.97 ± 1.08

1.62 ± 1.04

< 0.001

3.64 ± 1.25

1.93 ± 1.23

< 0.001

 Low

20 (40.8%)

21 (67.8%)

0.002

6 (14.3%)

21 (63.6%)

< 0.001

 Intermediate

29 (59.2%)

6 (19.4%)

0.002

26 (61.9%)

10 (30.3%)

0.003

 High

0

0

 

5 (11.9%)

0

0.058

HHT-score

2.24 ± 0.99

2.13 ± 0.86

0.599

2.35 ± 1.05

1.93 ± 0.82

0.058

 Mild

30 (61.2%)

21 (67.7%)

0.429

28 (66.7%)

25 (75.8%)

0.391

 Moderate

19 (38.8%)

9 (29%)

0.429

11 (26.2%)

8 (24.2%)

0.847

 Severe

0

0

 

3 (7.1%)

0

0.251

Invasive treatment,

 Pulmonary embolization

17 (34.7%)

12 (38.7%)

0.716

5 (11.9%)

0

0.063

 Brain embolization

1 (2%)

0

1.000

1 (2.4%)

0

1.000

 Liver  transplantation

0

0

 

1 (2.4%)

0

1.000

 Young surgery

0

0

 

1 (2.4%)

0

1.000

Anyone of the above

18 (36.7%)

12 (38.7%)

0.859

7 (16.7%)

0

0.016

Adverse outcomes,

 Hemoglobin < 8 g/dL or RBC transfusion

8 (16.3%)

5 (16.1%)

1.000

16 (38.1%)

11 (33.3%)

0.452

 ED visit

8 (16.3%)

11 (35.5%)

0.050

12 (28.6%)

16 (48.5%)

0.077

 Hospital admission

6 (12.2%)

8 (25.8%)

0.120

8 (19%)

3 (9.1%)

0.328

 Mortality

0

0

 

2 (4.8%)

1 (3%)

1.000

 Anyone of the above

17 (34.7%)

13 (41.9%)

0.515

22 (52.4%)

16 (48.5%)

0.738

  1. Abbreviations: EES Epistaxis Severity Score, RBC red blood cell, ED emergency department