Table 1 Clinical characteristics according to gender
From: Gender differences in hereditary hemorrhagic telangiectasia severity
Female N = 142 | Male N = 100 | P value | |
|---|---|---|---|
Clinical characteristics, | |||
Age, years (mean ± SD) | 48.9 ± 16.6 | 49 ± 16.5 | 0.995 |
Smoke (active or history) | 41 (28.9%) | 62 (62%) | < 0.001 |
Alcohol (active or history) | 6 (4.2%) | 24 (24%) | < 0.001 |
Hypertension | 34 (23.9%) | 25 (25%) | 0.851 |
Diabetes Mellitus | 8 (5.6%) | 14 (14%) | 0.026 |
Dyslipidemia | 38 (26.8%) | 29 (29%) | 0.701 |
Heart failure* | 5 (3.5%) | 2 (2%) | 0.703 |
Lung disease | 20 (14.1%) | 14 (14%) | 0.985 |
Cancer | 11 (7.7%) | 11 (11%) | 0.416 |
Venous thromboembolic disease | 2 (1.4%) | 4 (4%) | 0.240 |
Atrial fibrillation | 15 (10.6%) | 4 (4%) | 0.056 |
Curaçao criteria, | |||
Epistaxis | 134 (94.4%) | 99 (99%) | 0.085 |
Telangiectasia | 135 (95.1%) | 99 (99%) | 0.145 |
Visceral involvement | 119 (83.8%) | 73 (73%) | 0.056 |
Family history | 137 (96.5%) | 91 (91%) | 0.072 |
Curaçao criteria ≥3 | 135 (95.1%) | 97 (97%) | 0.315 |
Genetic test, | 102 (71.8%) | 70 (70%) | 0.757 |
ENG | 49 (34.5%) | 31 (31%) | 0.670 |
ACVRL1 | 42 (29.6%) | 33 (33%) | 0.407 |
Negative | 11 (7.7%) | 6 (6%) | 0.515 |
Blood test, | |||
Hemoglobin levels, g/dL (mean ± SD) | 12.5 ± 2.2 | 13.4 ± 2.9 | 0.007 |
Anemia** | 45 (31.7%) | 39 (39%) | 0.247 |
Iron deficiency*** | 85 (59.8%) | 59 (59%) | 0.937 |
AST, μkat/L (mean ± SD) | 0.35 ± 0.19 | 0.35 ± 0.12 | 0.874 |
AF, μkat/L (mean ± SD) | 1.36 ± 0.84 | 1.97 ± 7.82 | 0.455 |
Bilirubin, μmol/L (mean ± SD) | 8.67 ± 5.74 | 10.01 ± 7.10 | 0.133 |