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Table 4 Efficacy of pdC1-INH in 74 swellings versus 129 untreated attacks in 12 patients with HAE-PLG

From: Treatment of patients with hereditary angioedema with the c.988A>G (p.Lys330Glu) variant in the plasminogen gene

Patient numberNo. of untreated attacks*Mean duration of untreated attacks (hrs)No. of treated attacksNo. of attacks treated with 500 IU/1000 IU/1500 IU/3000 IU pdC1-INHMean time between attack onset and injection of icatibant (hrs)Mean time to first symptom relief (hrs)Mean duration of treated attacks (hrs)Mean shortening of attack duration attacks (%)No. of attacks shortened by > 50%No. of attacks shortened by 20–50%No. of attacks shortened by < 20%
Facial attacks
 11047.6204/16/0/01.72.645.34.80020
 210105.166/0/0/03.311882.9600
 141067.110/1/0/02.512464.2100
Tongue swellings
 11036.430/3/0/0453017.6003
 41017.342/0/1/110.354.5**0004
 15102.711/0/0/020.5162.7100
 161034.266/0/0/0211264.5510
 1734820/1/1/0612156.3200
 1869620/2/0/00.50.21287.5200
 191024.410/1/0/021675.4100
 201020.810/1/0/022448**0001
Abdominal attacks
 11027.7122/10/0/00.23.626.35.10210
 211084.350/5/0/0240.460.228.6302
 221081.9100/10/0/02.5122.272.9820
Total No.1297421/50/2/129540
  1. HAE hereditary angioedema, HAE-PLG HAE with normal C1-INH and the c.988A > G (p.K330E) variant in the plasminogen gene; pdC1-INH plasma-derived C1-INH, No. number
  2. *Last 10 attacks before treatment or all if less than 10
  3. **Severe and rapidly developing attacks
  4. Note: Out of the 74 swellings, 27 were facial swellings, 20 tongue swellings, and 27 abdominal attacks