Table 3 Efficacy of icatibant in 201 swellings versus 149 untreated attacks in 13 patients with HAE-PLG
Patient number | No. of untreated attacks* | Mean duration of untreated attacks (hrs) | No. of treated attacks | Mean time between attack onset and injection of icatibant (hrs) | Mean time to first symptom relief (hrs) | Mean duration of treated attacks (hrs) | Mean shortening of attack duration attacks (%) | No. of attacks shortened by > 50% | No. of attacks shortened by 20–50% | No. of attacks shortened by < 20% |
|---|---|---|---|---|---|---|---|---|---|---|
Facial attacks | ||||||||||
1 | 10 | 47.6 | 65 | 0.25 | 0.5 | 4.2 | 91.2 | 64 | 1 | 0 |
2 | 10 | 105.1 | 2 | 3.5 | 0.5 | 6.5 | 93.8 | 2 | 0 | 0 |
3 | 10 | 59.9 | 1 | 3 | 1 | 17 | 71.6 | 1 | 0 | 0 |
Tongue swellings | ||||||||||
1 | 10 | 36.4 | 41 | 0.25 | 0.5 | 4 | 89 | 40 | 1 | 0 |
4 | 10 | 17.3 | 1 | 1 | 0.5 | 6 | 65.3 | 1 | 0 | 0 |
5 | 10 | 35.1 | 52 | 1 | 0.25 | 4.3 | 87.7 | 52 | 0 | 0 |
6 | 10 | 13.3 | 1 | 3 | 7 | 13 | 2.3 | 0 | 0 | 1 |
7 | 10 | 30.2 | 2 | 1 | 0.5 | 3 | 90.1 | 2 | 0 | 0 |
8 | 6 | 70.2 | 2 | 2 | 0.3 | 2.5 | 96.4 | 2 | 0 | 0 |
9 | 3 | 37.7 | 1 | 0.5 | 0.5 | 3 | 92 | 1 | 0 | 0 |
10 | 10 | 3.1 | 1 | 0.3 | 0.3 | 3.1 | 1 | 0 | 0 | 1 |
11 | 10 | 31.1 | 1 | 0.5 | 0.2 | 2 | 93.6 | 1 | 0 | 0 |
12 | 10 | 55.9 | 1 | 1 | 0.5 | 4 | 92.8 | 1 | 0 | 0 |
13 | 10 | 72.5 | 1 | 0.5 | 0.5 | 1 | 98.6 | 1 | 0 | 0 |
Abdominal attacks | ||||||||||
1 | 10 | 27.7 | 27 | 0.2 | 0.5 | 4.4 | 84.1 | 27 | 0 | 0 |
3 | 10 | 77.9 | 2 | 1 | 0.5 | 1.5 | 98.1 | 2 | 0 | 0 |
Total No. | 149 | – | 201 | – | – | – | – | 197 | 2 | 2 |