Table 3 Results of low molecular plasma parameters in adult PKU patients compared to controls. Significant differences were set to p < 0.05 (t-test)
Metabolite (μmol/L) | Controls (n = 14) | Patients (n = 22) | p-value | ||
|---|---|---|---|---|---|
Mean | SD | Mean | SD | ||
Phenylalanine | 49.2 | 10.1 | 830.7 | 503 | 0.00000 |
DL-Tyrosine | 56.9 | 7.8 | 42.6 | 18.7 | 0.00514 |
Glutamine | 690.6 | 88.4 | 611.4 | 99.1 | 0.01013 |
Glutamic acid | 50.5 | 29.2 | 87.7 | 57.3 | 0.01596 |
Creatinine | 86.1 | 12.7 | 74.8 | 16 | 0.01647 |
Citric acid | 157.2 | 30.9 | 186.9 | 45.4 | 0.01952 |
3-Hydroxybutyric acid | 47.6 | 34 | 83.9 | 102.3 | 0.10514 |
Acetoacetic acid | 10.1 | 14.3 | 19.8 | 30 | 0.13468 |
L-Isoleucine | 50.1 | 15.6 | 45.3 | 11.5 | 0.14610 |
Creatine | 15.6 | 10.2 | 11.8 | 11.2 | 0.15723 |
Histidine | 76.9 | 25.5 | 90.7 | 72 | 0.24784 |
Ethanol | 107.2 | 55.5 | 117.1 | 45.1 | 0.28115 |
Pyruvic acid | 89 | 38.5 | 96.7 | 38.9 | 0.28319 |
Alanine | 415.5 | 116.5 | 432.8 | 89.7 | 0.31004 |
Trimethylamine-N-oxide | 21.3 | 16.9 | 18.3 | 17.7 | 0.31144 |
Leucine | 93.1 | 23.5 | 89.1 | 24.4 | 0.31443 |
Formic acid | 17.5 | 6 | 16.7 | 4.5 | 0.32376 |
Threonine | 59.8 | 99.2 | 69.5 | 64.2 | 0.36175 |
Acetone | 23.3 | 10.5 | 21.5 | 18.7 | 0.37320 |
Valine | 218.4 | 43.9 | 222.4 | 60.4 | 0.41777 |
Glycine | 311.5 | 101.2 | 318.7 | 99.8 | 0.41813 |
Acetic acid | 19.1 | 16 | 17.9 | 17.6 | 0.41959 |
D-Glucose | 4904.1 | 481 | 4830.8 | 1188 | 0.41409 |
Lactic acid | 2409.7 | 405.2 | 3033 | 1646.8 | 0.08787 |