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Table 4 Biochemical variables of study participants, stratified by genetic test results

From: Can we identify individuals with an ALPL variant in adults with persistent hypophosphatasaemia?

Biochemical variables, [Median (IQR)]+GT* (N = 39)–GT* (N = 45)Total (N = 84)p value
ALP*, IU/L (N = 39, 45, 84)26 (22–29)29 (27–32)28 (25–31)0.001**
  <  20 IU/L6 (15%)0 (0%)6 (7.1%) 
  < 25 IU/L17 (44%)1 (2%)18 (21%) 
  < 30 IU/L32 (82%)25 (56%)57 (68%) 
  <  35 IU/L38 (97%)43 (96%)81 (96%) 
Calcium, mg/dL (N = 34, 44, 78)9.4 (9.1–9.7)9.2 (9.1–9.4)9.3 (9.1–9.6)0.251
Phosphate, mg/dL (N = 20,24,44)4 (3.5–4.5)3.4 (3.1–4.1)3.6 (3.2–4.3)0.016**
Creatinine, mg/dL (N = 36, 39,75)0.91 (0.9–1)0.9 (0.8–1)0.9 (0.9–1)0.053
Urinary calcium excretion, mg/24 h (N = 4, 1, 5)84.5 (22.6–98)123 (123–123)89 (41.7–112)0.400
Urinary phosphate excretion, mg/24 h (N = 3, 0, 3)35 (32.6)35 (32.6)
  1. *GT positive genetic test, −GT negative genetic test, ALP Alkaline phosphatase. **Significant statistical differences between groups