Table 4 Biochemical variables of study participants, stratified by genetic test results
From: Can we identify individuals with an ALPL variant in adults with persistent hypophosphatasaemia?
Biochemical variables, [Median (IQR)] | +GT* (N = 39) | –GT* (N = 45) | Total (N = 84) | p value |
|---|---|---|---|---|
ALP*, IU/L (N = 39, 45, 84) | 26 (22–29) | 29 (27–32) | 28 (25–31) | 0.001** |
< 20 IU/L | 6 (15%) | 0 (0%) | 6 (7.1%) | |
< 25 IU/L | 17 (44%) | 1 (2%) | 18 (21%) | |
< 30 IU/L | 32 (82%) | 25 (56%) | 57 (68%) | |
< 35 IU/L | 38 (97%) | 43 (96%) | 81 (96%) | |
Calcium, mg/dL (N = 34, 44, 78) | 9.4 (9.1–9.7) | 9.2 (9.1–9.4) | 9.3 (9.1–9.6) | 0.251 |
Phosphate, mg/dL (N = 20,24,44) | 4 (3.5–4.5) | 3.4 (3.1–4.1) | 3.6 (3.2–4.3) | 0.016** |
Creatinine, mg/dL (N = 36, 39,75) | 0.91 (0.9–1) | 0.9 (0.8–1) | 0.9 (0.9–1) | 0.053 |
Urinary calcium excretion, mg/24 h (N = 4, 1, 5) | 84.5 (22.6–98) | 123 (123–123) | 89 (41.7–112) | 0.400 |
Urinary phosphate excretion, mg/24 h (N = 3, 0, 3) | 35 (32.6) | – | 35 (32.6) | – |