From: Can we identify individuals with an ALPL variant in adults with persistent hypophosphatasaemia?
Clinical feature, n (%) | +GT* (N = 39) | –GT* (N = 45) | Total (N = 84) | p value |
---|---|---|---|---|
Musculoskeletal pain | 31 (79.5%) | 21 (46.7%) | 52 (61.9%) | 0.002** |
Fractures | ||||
History of fractures | 17 (43.6%) | 15 (33.3%) | 32 (38.1%) | 0.334 |
Multiple fractures | 2 (5.0%) | 0 (0.0%) | 2 (2.4%) | 0.129 |
Peripheral fractures | 18 (45.0%) | 13 (28.9%) | 31 (36.5%) | 0.124 |
Metatarsal fractures | 4 (10.0%) | 0 | 4 (4.7%) | 0.007** |
Family history of fractures | 6 (15.8%) | 9 (20.0%) | 15 (18.1%) | 0.619 |
Orthopedic surgery | 7 (18.4%) | 2 (4.4%) | 9 (10.8%) | 0.041** |
History of premature teeth loss | 6 (15.4%) | 1 (2.2%) | 7 (8.3%) | 0.029** |
Dental abnormalities | 12 (31.6%) | 6 (13.3%) | 18 (21.7%) | 0.045** |
Family history of dental problems | 11 (35.5%) | 14 (34.1%) | 25 (34.7%) | 0.906 |
Muscle weakness | 6 (15.4%) | 3 (6.7%) | 9 (10.7%) | 0.198 |
Calcific periarthritis | 4 (10.3%) | 3 (6.7%) | 7 (8.3%) | 0.553 |
Chondrocalcinosis | 2 (5,1%) | 0 | 2 (2,4%) | 0.124 |
Median VAS* (IQR) | 3 (2–5) | 1 (0–5) | 2 (0–5) | 0.038** |
Median HAQ-DI* (IQR) | 0 (0–0.3) | 0 (0–0.1) | 0 (0–0.3) | 0.872 |