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Table 1 Factors associated with a poor MPNST prognosis

From: Neurofibromatosis 1 French national guidelines based on an extensive literature review since 1966

Factors associated with a poor MPNST prognosis
 Clinical and radiologicalSite: axial/trunk [99,100,101]
More than one primary tumor [102]
Larger tumor size [99, 101,102,103]
 HistologicalHigh histological grade [101, 102]
 GenotypicTelomerase activity and overexpression of TERT[104]
Genomic changes in chromosomes 10, 16, and X [105]
  1. TERT Telomerase reverse transcriptase