Outcomes of interest | Studies, no. | Treated Eyes, no. | Untreated Eyes, no. | WMD/RR (95%CL) | P value | Study heterogeneity | |||
---|---|---|---|---|---|---|---|---|---|
χ2 | df | I2, % | P value | ||||||
Main outcomes | |||||||||
Mean BCVA change at 1 year | 4 | 57 | 41 | −0.10 (−0.17 to −0.04) | 0.002 | 8.88 | 5 | 44 | 0.11 |
Mean BCVA change at 2–3 years | 4 | 31 | 32 | 0.01 (−0.00 to 0.02) | 0.15 | 6.80 | 5 | 27 | 0.24 |
Other outcomes | |||||||||
FST sensitivity to red flashes | 2 | 37 | 21 | 0.86 (−0.29 to 2.01) | 0.14 | 18.32 | 1 | 95 | <0.0001 |
FST sensitivity to blue flashes | 2 | 37 | 21 | 1.60 (0.66 to 2.55) | 0.0009 | 3.25 | 1 | 69 | 0.07 |
Change in central retinal thickness at 1 year | 2 | 52 | 30 | −11.68 (−32.49 to 9.14) | 0.27 | 4.21 | 1 | 76 | 0.04 |
Change in central retinal thickness at 2–3 years | 2 | 18 | 18 | −19.21 (−34.22 to −4.20) | 0.01 | 0.38 | 1 | 0 | 0.54 |