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Table 1 Results of meta-analysis comparison of treated and untreated group

From: The effect of human gene therapy for RPE65-associated Leber’s congenital amaurosis on visual function: a systematic review and meta-analysis

Outcomes of interest

Studies, no.

Treated Eyes, no.

Untreated Eyes, no.

WMD/RR (95%CL)

P value

Study heterogeneity

χ2

df

I2, %

P value

Main outcomes

 Mean BCVA change at 1 year

4

57

41

−0.10 (−0.17 to −0.04)

0.002

8.88

5

44

0.11

 Mean BCVA change at 2–3 years

4

31

32

0.01 (−0.00 to 0.02)

0.15

6.80

5

27

0.24

Other outcomes

 FST sensitivity to red flashes

2

37

21

0.86 (−0.29 to 2.01)

0.14

18.32

1

95

<0.0001

 FST sensitivity to blue flashes

2

37

21

1.60 (0.66 to 2.55)

0.0009

3.25

1

69

0.07

 Change in central retinal thickness at 1 year

2

52

30

−11.68 (−32.49 to 9.14)

0.27

4.21

1

76

0.04

 Change in central retinal thickness at 2–3 years

2

18

18

−19.21 (−34.22 to −4.20)

0.01

0.38

1

0

0.54