Table 2 Nuclear genes involved in other mitochondrial functions causing Leigh and Leigh-like syndrome
Mitochondrial function | Associated nuclear genes |
|---|---|
Mitochondrial DNA maintenance | FBXL4, POLG, POLG2, SUCLA2, SUCLG1, TWNK, SLC25A4, MPV17 |
Mitochondrial translation | GTPBP3, TRMU, EARS2, FARS2, IARS2, GFM1, GFM2, LRPPRC,TACO1, MTFMT, C12Orf65, MRPS34, MRPS39 (PTCD3), NARS2, TSFM |
Mitochondrial dynamics | SLC25A46, DNM1L, MFN2, RRM2B |
Mitochondrial material import/export | SLC25A19 |
Membrane phosphocomponents | SERAC1 |
Sulfur dioxygenase | ETHE1 |
AAA oligomeric +/− ATPase | CLPB, SPG7 |
RNA import | PNPT1 |
RNA-specific adenosine deaminase | ADAR, RNASEH1 |
Nuclear translocation system | RANBP2 |
Nuclear pore complex | NUP62 |
Manganese transportation | SLC39A8 |