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Table 6 Mutation spectrum of β-globin gene in the β-thalassemia and HbE carriers in Bangladeshi population

From: Nationwide carrier detection and molecular characterization of β-thalassemia and hemoglobin E variants in Bangladeshi population

SL No.

Mutation Pattern

Number of samples, n (%; 95% CI)

1

c.79G > A (HbE)

163 (73.42; 67.62–79.22)

2

c.92 + 5G > C

32 (14.41; 9.8–19.02)

3

c.79G > A + c.79G > A

8 (3.61; 1.16–6.06)

4

c.92 + 130G > C

01 (0.45; 0.43–1.33)

5

c.151A > G a

01 (0.45; 0.43–1.33)

6

c.126_129delCTTT

03 (1.35; 0.16–2.86)

7

c.27_28insG

02 (0.90; 0.34–2.14)

8

c.47G > A

03 (1.35; 0.16–2.86)

9

c.79G > A + c.92 + 5G > C

02 (0.90; 0.34–2.14)

  1. anovel mutation; not reported in Bangladeshi population and also globally [23]