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Table 5 Comparison of sensitivity and specificity among the conventional hematological-analysis based approaches for thalassemia carrier detection

From: Nationwide carrier detection and molecular characterization of β-thalassemia and hemoglobin E variants in Bangladeshi population

Screening method

Mean sensitivity, % (95% CI)

Mean specificity, % (95% CI)

Positive predictive value, % (95% CI)

Negative predictive value,% (95% CI)

Diagnostic accuracy, % (95% CI)

True +ve (n)

False + ve (n)

True –ve (n)

False -ve(n)

MCV + MCH only

96.04 (92.64–97.9)

59.76 (57.37–62.17)

24.72 (21.98–27.67)

99.1 (98.29–99.52)

64.14 (61.95–66.28)

218

664

986

9

Hb electrophoresis

99.55 (97.51–99.92)

99.7 (99.29–99.87)

97.81 (94.97–99.06)

99.94 (99.66–99.99)

99.68 (99.3–99.85)

223

05

1648

01

MCV+ MCH and Hb Electrophoresis

99.55 (97.51–99.92)

99.82 (99.47–99.94)

98.67 (96.17–99.55)

99.94 (99.52–99.96)

99.79 (99.66–99.99)

223

03

1650

01

  1. CI Confidence Interval, MCV Mean corpuscular volume, MCH Mean corpuscular hemoglobin