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Table 5 Comparison of sensitivity and specificity among the conventional hematological-analysis based approaches for thalassemia carrier detection

From: Nationwide carrier detection and molecular characterization of β-thalassemia and hemoglobin E variants in Bangladeshi population

Screening methodMean sensitivity, % (95% CI)Mean specificity, % (95% CI)Positive predictive value, % (95% CI)Negative predictive value,% (95% CI)Diagnostic accuracy, % (95% CI)True +ve (n)False + ve (n)True –ve (n)False -ve(n)
MCV + MCH only96.04 (92.64–97.9)59.76 (57.37–62.17)24.72 (21.98–27.67)99.1 (98.29–99.52)64.14 (61.95–66.28)2186649869
Hb electrophoresis99.55 (97.51–99.92)99.7 (99.29–99.87)97.81 (94.97–99.06)99.94 (99.66–99.99)99.68 (99.3–99.85)22305164801
MCV+ MCH and Hb Electrophoresis99.55 (97.51–99.92)99.82 (99.47–99.94)98.67 (96.17–99.55)99.94 (99.52–99.96)99.79 (99.66–99.99)22303165001
  1. CI Confidence Interval, MCV Mean corpuscular volume, MCH Mean corpuscular hemoglobin