Nationwide carrier detection and molecular characterization of β-thalassemia and hemoglobin E variants in Bangladeshi population

Table 3 Molecular analysis of the selected participants for confirmation of the carrier status

Groups	Selection parameters	Total, n	Mutation Absent, n	Number of participants having mutation in β-globin gene, n
Groups	Selection parameters	Total, n	Mutation Absent, n	Heterozygous	Homozygous^a/compound heterozygous^b
Group 1	HbA2 < 2.2% Hb < 10 g/dl	64	64	0	0
Group 2	Hb A2: 3.3–3.5% (borderline suspected)	25	24	01	0
Group 3	HbA2 > 3.5%	46	05	41	0
Group 4	HbE: 25–40%	165	0	163	2^b
Group 5	HbE > 90% HbA = 0%	08	0	0	8^a

Hb Hemoglobin; ^a indicates the presence of two mutations in homozygous condition and ^b indicates the presence of compound heterozygous mutation

ISSN: 1750-1172