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Table 1 Main challenges identified in Paediatric Transplantation

From: Cross-cutting view of current challenges in paediatric solid organ and haematopoietic stem cell transplantation in Europe: the European Reference Network TransplantChild

Main challengesDescriptionChallenges classification and terms
Post-transplant morbidity and mortalityMortality and morbidity rates are still high in childrenClinical - short-term
Longer life expectancy in childrenChildren poses a greater risk of prolonged and severe side effects related to long-term immunosuppression, disabilities and secondary cancer [7, 8]Clinical – medium/long-term
Physiological ImmaturityMany organs and body systems, specially the immune, metabolic and endocrinology systems, impact on the growing and developmental processClinical – medium/long-term
Risk factors during adolescenceDisruptions in the continuity of medical provision during such a delicate developmental period.Social – medium/long-term
Transition to adulthoodAdditional transitional programmes are needed in order to ensure active collaboration between paediatric and adult transplant programs.Clinical – medium/long-term
Psychosocial progress and social integrationSevere psychological and socio-economic issues could be identified during the transplant process.Social – medium/long-term
Health-related quality of life (HRQoL) acceptable but lower than their healthy peersHRQoL of patients and parents that taking care of transplanted children can be seriously impaired, mainly in the ability to perform tasks of daily living, to fulfil social roles, and the psychological well-being of the patients.Social – medium/long-term