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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: A new UHPLC-MS/MS method for the screening of urinary oligosaccharides expands the detection of storage disorders

Fig. 2

Scatter charts of the most characteristic transitions in disorders showing specific OS profiles. The figure shows for each storage disorders the most characteristic MRM transitions in urine and DUS in comparison to controls: a sialidosis: transition 1200.4 > 1099.4 of the sialyl-OS NeuAc-Hex3HexNAc2; b α-mannosidosis: transition 568.2 > 347.2 of the mannosyl-OS NeuAc-Hex3HexNAc2; c fucosidosis: transition 504.2 > 289.2 of the fucosyl-OS Fuc-HexNAc-Asn; d β-mannosidosis: transition 406 > 244 of Hex-HexNAc and derivatives; e aspartylglucosaminuria: transition 520.2 > 305.2 of the GlcN-Asn + glycoasparaginyl-OS Hex-HexNAc-Asn; f GM1 gangliosidosis: transition 933.5 > 388.3 of the galactosyl-OS Hex3-HexNAc2; g GM2 gangliosidosis, Sandhoff type: transition 1136.3 > 933.4 of the N-acetylgalactosaminyl-OS Hex3-H; h GM2 gangliosidosis, Tay-Sachs type lacking the increase of the transition 1136.3 > 933.4 of the N-acetylgalactosaminyl-OS Hex3-HexNAc3 as seen in GM2 Sandhoff type

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