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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: A new UHPLC-MS/MS method for the screening of urinary oligosaccharides expands the detection of storage disorders

Fig. 1

Chromatographic profiles of the examined storage disordes and of the internal standard (IS). The characteristic MRM transitions, in positive (+) and negative (−) modes, for each disorder are marked with different colours. Panel A: (1) extract ion chromatogram (XIC) of the seven positive MRM transitions characteristic for the IS maltoheptaose Glc7; (2) XIC of the seven negative MRM transitions characteristic for Glc7; (3) XIC of the three negative MRM transitions characteristic for sialidosis; (4) XIC of the eight positive MRM transitions characteristic for α-mannosidosis; (5) XIC of the nine positive MRM transitions characteristic for β-mannosidosis; (6) XIC of the eight negative MRM transitions characteristic for β-mannosidosis. Panel B: (7) XIC of the six positive MRM transitions characteristic for fucosidosis; (8) XIC of the two negative MRM transitions characteristic for Pompe disease, Vici syndrome, Yunis-Varon syndrome, and Danon disease; (9) XIC of the five positive MRM transitions characteristic for aspartylglucosaminuria; (10) XIC of the ten negative MRM transitions characteristic for aspartylglucosaminuria; (11) XIC of the five positive MRM transitions characteristic for GM1 gangliosidosis; (12) XIC of the seven positive MRM transitions characteristic for GM2 gangliosidosis

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