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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: The natural history of Canavan disease: 23 new cases and comparison with patients from literature

Fig. 1

Clinical features at onset of disease in the cohort of 23 CD patients. Bars indicate the number of patients that developed the symptom. ** 23/23 patients in the study group showed a combination of 6 symptoms in median (range 2–12 symptoms) at onset of disease. * 4/23 patients showed a combination of low muscle tone (axial hypotonia) and high muscle tone (appendicular hypertonia). 6/23 patients showed only high muscle tone. 8/23 patients showed only low muscle tone

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