Skip to main content

Table 2 Duration of follow-up, GRAF score, and association of GRAF score with fracture risk, by ATI

From: The International Collaborative Gaucher Group GRAF (Gaucher Risk Assessment for Fracture) score: a composite risk score for assessing adult fracture risk in imiglucerase-treated Gaucher disease type 1 patients

 

N

Years of follow-up

GRAF score

GRAF score association with fracture risk1

Median (25%, 75%)

Median (25%, 75%)

HR (95% CI), p-value

ATI < 18 years cohort

 Total sample

656

7.9 (3.5, 13.9)

0.7 (0.4, 1.0)

 

 Patients w/ any type of fracture

33

4.5 (2.3, 8.6)

0.8 (0.7, 1.1)

All types of fracture

2.72 (1.14, 6.50), 0.0246

 Patients w/spinal fracture

12

4.4 (1.3, 6.6)

0.9 (0.7, 1.2)

Spinal fracture

3.87 (0.92, 16.20), 0.0643

ATI ≥ 18 to < 50 years cohort

 Total sample

1485

13.8 (5.7, 20.1)

1.2 (0.9, 1.6)

 

 Patients w/ any type of fracture

167

6.4 (2.0, 13.7)

1.5 (1.2, 1.9)

All types of fracture

2.72 (2.06, 3.58), < 0.0001

 Patients w/spinal fracture

61

6.0 (2.0, 12.9)

1.5 (1.3, 2.0)

Spinal fracture

3.44 (2.20, 5.38), < 0.0001

ATI ≥ 50 years cohort

 Total sample

507

8.2 (4.1, 14.3)

2.8 (2.3, 3.2)

 

 Patients w/any type of fracture

88

4.8 (1.7, 9.4)

3.1 (2.7, 3.6)

All types of fracture

2.72 (1.92, 3.84), < 0.0001

 Patients w/spinal fracture

34

4.9 (1.1, 10.6)

3.1 (2.7, 3.6)

Spinal fracture

2.84 (1.62, 4.99), 0.0003

  1. Abbreviations: ATI = age at treatment initiation; CI = confidence interval; GRAF = Gaucher Risk Assessment for Fracture; HR = hazard ratio
  2. 1HR and 95% CI estimated using Cox proportional hazards regression from age at treatment initiation (or age 18 years for patients initiating therapy prior to 18 years) to first fracture in adulthood, death, or end of follow-up. For each 1 unit increase in GRAF score, the fracture risk increases by 272% (HR = 2.72 across all ATI cohorts)