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Table 4 Association between BDNF/NfL and cerebral blood flow at the same visit, adjusted for age

From: Fingolimod in children with Rett syndrome: the FINGORETT study

Brain region Source Estimate SE CI p
BDNF      
 Cortex* Serum 0.10 0.55 [− 0.984; 1.185] 0.856
CSF 1.42 0.94 [− 0.415; 3.261] 0.129
 Insula Serum 0.35 0.59 [− 0.800; 1.505] 0.549
CSF 1.19 1.00 [− 0.761; 3.145] 0.232
 Occipital Serum − 0.20 0.74 [− 1.652; 1.260] 0.792
CSF 2.27 1.44 [− 0.547; 5.091] 0.114
 Parietal Serum 0.06 0.49 [− 0.904; 1.033] 0.896
CSF 1.59 0.87 [− 0.119; 3.309] 0.068
 Temporal Serum − 0.25 0.55 [− 1.327; 0.823] 0.646
CSF 1.21 1.02 [− 0.791; 3.219] 0.235
 Basal ganglia Serum − 0.08 0.26 [− 0.589; 0.432] 0.763
CSF 0.94 0.38 [0.199; 1.673] 0.013
 Thalamus Serum 0.02 0.77 [− 1.487; 1.535] 0.975
CSF 3.11 1.14 [0.867; 5.351] < 0.01
 Hippo-campus Serum − 0.02 0.47 [− 0.950; 0.912] 0.967
CSF 1.12 0.69 [− 0.224; 2.464] 0.102
NfL
 Cortex* Serum − 0.58 0.11 [− 0.796;  − 0.368] < 0.01
CSF − 0.01 0.01 [− 0.023;  − 0.002] 0.018
 Insula Serum − 0.40 0.11 [− 0.610;  − 0.196] < 0.01
CSF − 0.01 0.00 [− 0.017;  − 0.005] < 0.01
 Occipital Serum − 0.91 0.14 [− 1.185;  − 0.637] < 0.01
CSF − 0.02 0.01 [− 0.034; 0.000] 0.049
 Parietal Serum − 0.70 0.14 [− 0.970;  − 0.434] < 0.01
CSF − 0.10 0.01 [− 0.025;  − 0.003] 0.011
 Temporal Serum − 0.65 0.11 [− 0.861;  − 0.449] < 0.01
CSF − 0.01 0.01 [− 0.025;  − 0.004] < 0.01
 Basal ganglia Serum − 0.38 0.07 [− 0.519;  − 0.237] < 0.01
CSF − 0.01 0.00 [− 0.014;  − 0.003] < 0.01
 Thalamus Serum − 0.53 0.14 [− 0.810;  − 0.251] < 0.01
CSF − 0.01 0.01 [− 0.026;  − 0.002] 0.019
 Hippo-campus Serum − 0.47 0.10 [− 0.661;  − 0.269] < 0.01
CSF − 0.02 0.00 [− 0.023;  − 0.008] < 0.01
  1. *Cortex: includes cortex of Insula, occipital, parietal, and temporal lobes. Frontal cortex evaluation was not possible due to susceptibility artefacts