Fingolimod in children with Rett syndrome: the FINGORETT study

Table 3 Association between BDNF/NfL and deep gray matter volumes at the same visit, adjusted for age

Brain region	Source	Estimate	SE	CI	p
BDNF
Thalamus	Serum	− 145.97	117.07	[− 375.429; 83.493]	0.212
Thalamus	CSF	214.06	139.28	[− 58.925; 487.047]	0.124
Caudate	Serum	− 53.78	43.26	[− 138.569; 30.999]	0.214
Caudate	CSF	36.72	55.75	[− 72.561; 145.994]	0.510
Putamen	Serum	− 51.60	82.04	[− 212.397; 109.191]	0.529
Putamen	CSF	91.56	107.25	[− 118.650; 301.763]	0.393
Pallidum	Serum	− 24.99	30.76	[− 85.287; 35.303]	0.417
Pallidum	CSF	59.34	39.40	[− 17.888; 136.572]	0.132
Hippocampus	Serum	− 91.05	43.22	[− 175.764; − 6.333]	0.035
Hippocampus	CSF	− 13.73	64.68	[− 140.512; 113.046]	0.832
Amygdala	Serum	− 16.06	23.46	[− 62.032; 29.920]	0.494
Amygdala	CSF	16.23	27.50	[− 37.673; 70.130]	0.555
Accumbens	Serum	− 20.76	4.89	[− 30.355; − 11.171]	< 0.01
Accumbens	CSF	15.93	11.83	[− 7.255; 39.124]	0.178
NfL
Thalamus	Serum	− 79.96	34.05	[− 146.704; − 13.216]	0.019
Thalamus	CSF	− 2.41	0.81	[− 3.994; − 0.829]	< 0.01
Caudate	Serum	− 37.81	12.57	[− 62.440; − 13.185]	< 0.01
Caudate	CSF	− 1.14	0.30	[− 1.735; − 0.554]	< 0.01
Putamen	Serum	− 33.13	24.04	[− 80.253; 13.985]	0.168
Putamen	CSF	− 1.45	0.44	[− 2.318; − 0.588]	< 0.01
Pallidum	Serum	− 24.58	8.60	[− 41.442; − 7.717]	< 0.01
Pallidum	CSF	− 0.74	0.20	[− 1.127; − 0.349]	< 0.01
Hippocampus	Serum	− 56.13	14.14	[− 83.846; − 28.409]	< 0.01
Hippocampus	CSF	− 1.12	0.55	[− 2.195; − 0.048]	0.041
Amygdala	Serum	− 8.60	6.66	[− 21.652; 4.457]	0.197
Amygdala	CSF	− 0.40	0.14	[− 0.682; − 0.124]	< 0.01
Accumbens	Serum	− 6.88	2.51	[− 11.803; − 1.948]	< 0.01
Accumbens	CSF	− 0.11	0.10	[− 0.300; 0.081]	0.261

ISSN: 1750-1172