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Table 3 Association between BDNF/NfL and deep gray matter volumes at the same visit, adjusted for age

From: Fingolimod in children with Rett syndrome: the FINGORETT study

Brain region Source Estimate SE CI p
BDNF      
 Thalamus Serum − 145.97 117.07 [− 375.429; 83.493] 0.212
CSF 214.06 139.28 [− 58.925; 487.047] 0.124
 Caudate Serum − 53.78 43.26 [− 138.569; 30.999] 0.214
CSF 36.72 55.75 [− 72.561; 145.994] 0.510
 Putamen Serum − 51.60 82.04 [− 212.397; 109.191] 0.529
CSF 91.56 107.25 [− 118.650; 301.763] 0.393
 Pallidum Serum − 24.99 30.76 [− 85.287; 35.303] 0.417
CSF 59.34 39.40 [− 17.888; 136.572] 0.132
 Hippocampus Serum − 91.05 43.22 [− 175.764;  − 6.333] 0.035
CSF − 13.73 64.68 [− 140.512; 113.046] 0.832
 Amygdala Serum − 16.06 23.46 [− 62.032; 29.920] 0.494
CSF 16.23 27.50 [− 37.673; 70.130] 0.555
 Accumbens Serum − 20.76 4.89 [− 30.355;  − 11.171] < 0.01
CSF 15.93 11.83 [− 7.255; 39.124] 0.178
NfL
 Thalamus Serum − 79.96 34.05 [− 146.704;  − 13.216] 0.019
CSF − 2.41 0.81 [− 3.994;  − 0.829]  < 0.01
 Caudate Serum − 37.81 12.57 [− 62.440;  − 13.185]  < 0.01
CSF − 1.14 0.30 [− 1.735;  − 0.554]  < 0.01
 Putamen Serum − 33.13 24.04 [− 80.253; 13.985] 0.168
CSF − 1.45 0.44 [− 2.318;  − 0.588] < 0.01
 Pallidum Serum − 24.58 8.60 [− 41.442;  − 7.717] < 0.01
CSF − 0.74 0.20 [− 1.127;  − 0.349] < 0.01
 Hippocampus Serum − 56.13 14.14 [− 83.846;  − 28.409] < 0.01
CSF − 1.12 0.55 [− 2.195;  − 0.048] 0.041
 Amygdala Serum − 8.60 6.66 [− 21.652; 4.457] 0.197
CSF − 0.40 0.14 [− 0.682;  − 0.124] < 0.01
 Accumbens Serum − 6.88 2.51 [− 11.803;  − 1.948] < 0.01
CSF − 0.11 0.10 [− 0.300; 0.081] 0.261