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Table 2 Overview of CLMs

From: Hereditary leiomyomatosis and renal cell carcinoma: a case series and literature review

Characteristic Reported value (%)
CLM reported (n = 672)  
 Yes 474 (70.5%)
 No 189 (28.1%)
 NA1 9 (1.4%)
 CLM mean age at onset, mean ± SD (range) 28.4 years ± 11.08 (11–79 years) (n = 120)
CLM number  
 Few (< 5) 6/474 (1.3%)
 Multiple (≥ 5) 91/474 (19.2%)
 NA 377/474 (79.5%)
CLM symptoms  
 Asymptomatic 31/474 (6.5%)
 Painful 124/474 (26.2%)
 Pruritic 14/474 (3%)
 Painful and pruritic 2/474 (0.4%)
 NA 303/474 (63.9%)
CLM painful stimuli2  
 Pain in response to tactile stimuli (touch, pressure) 48/121 (39.7%)
 Pain in response to unspecified temperature changes 4/121 (3.3%)
 Pain in response to cold 56/121 (46.3%)
 Pain in response to heat 10/121 (8.2%)
 Pain in response to emotional stress 3/121 (2.5%)
CLM distribution2  
 Head and neck 33/300 (11%)
 Trunk 119/300 (39.7%)
 Upper limbs (including shoulders) 80/300 (26.7%)
 Lower limbs (including buttocks and genitals) 68/300 (22.6%)
  1. 1Not available (NA) data due to lack of mention in the case reports and cohort studies
  2. 2CLM painful stimuli and CLM distribution were not known for all patients. Furthermore, most cases had more than one pain triggering stimuli and more than one location which was affected by CLMs.