From: Hereditary leiomyomatosis and renal cell carcinoma: a case series and literature review
Characteristic | Reported value (%) |
---|---|
CLM reported (n = 672) | |
Yes | 474 (70.5%) |
No | 189 (28.1%) |
NA1 | 9 (1.4%) |
CLM mean age at onset, mean ± SD (range) | 28.4 years ± 11.08 (11–79 years) (n = 120) |
CLM number | |
Few (< 5) | 6/474 (1.3%) |
Multiple (≥ 5) | 91/474 (19.2%) |
NA | 377/474 (79.5%) |
CLM symptoms | |
Asymptomatic | 31/474 (6.5%) |
Painful | 124/474 (26.2%) |
Pruritic | 14/474 (3%) |
Painful and pruritic | 2/474 (0.4%) |
NA | 303/474 (63.9%) |
CLM painful stimuli2 | |
Pain in response to tactile stimuli (touch, pressure) | 48/121 (39.7%) |
Pain in response to unspecified temperature changes | 4/121 (3.3%) |
Pain in response to cold | 56/121 (46.3%) |
Pain in response to heat | 10/121 (8.2%) |
Pain in response to emotional stress | 3/121 (2.5%) |
CLM distribution2 | |
Head and neck | 33/300 (11%) |
Trunk | 119/300 (39.7%) |
Upper limbs (including shoulders) | 80/300 (26.7%) |
Lower limbs (including buttocks and genitals) | 68/300 (22.6%) |