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Table 2 Overview of CLMs

From: Hereditary leiomyomatosis and renal cell carcinoma: a case series and literature review

Characteristic

Reported value (%)

CLM reported (n = 672)

 

 Yes

474 (70.5%)

 No

189 (28.1%)

 NA1

9 (1.4%)

 CLM mean age at onset, mean ± SD (range)

28.4 years ± 11.08 (11–79 years) (n = 120)

CLM number

 

 Few (< 5)

6/474 (1.3%)

 Multiple (≥ 5)

91/474 (19.2%)

 NA

377/474 (79.5%)

CLM symptoms

 

 Asymptomatic

31/474 (6.5%)

 Painful

124/474 (26.2%)

 Pruritic

14/474 (3%)

 Painful and pruritic

2/474 (0.4%)

 NA

303/474 (63.9%)

CLM painful stimuli2

 

 Pain in response to tactile stimuli (touch, pressure)

48/121 (39.7%)

 Pain in response to unspecified temperature changes

4/121 (3.3%)

 Pain in response to cold

56/121 (46.3%)

 Pain in response to heat

10/121 (8.2%)

 Pain in response to emotional stress

3/121 (2.5%)

CLM distribution2

 

 Head and neck

33/300 (11%)

 Trunk

119/300 (39.7%)

 Upper limbs (including shoulders)

80/300 (26.7%)

 Lower limbs (including buttocks and genitals)

68/300 (22.6%)

  1. 1Not available (NA) data due to lack of mention in the case reports and cohort studies
  2. 2CLM painful stimuli and CLM distribution were not known for all patients. Furthermore, most cases had more than one pain triggering stimuli and more than one location which was affected by CLMs.